An Australian twin study of cannabis and other illicit drug use and misuse, and other psychopathology.
An Australian twin study of cannabis and other illicit drug use and misuse, and other psychopathology.
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DOI：
10.1017/thg.2012.41
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发表时间：
2012-10
影响因子：
0.9
通讯作者：
Martin, Nicholas G.
中科院分区：
文献类型：
--
作者：
Lynskey, Michael T.;Agrawal, Arpana;Henders, Anjali;Nelson, Elliot C.;Madden, Pamela A. F.;Martin, Nicholas G.
大麻是整个发达世界使用最广泛的非法药物，有一致的证据表明，大麻参与的多个阶段，包括开始使用和滥用/依赖，都受到遗传影响。在本文中，我们描述了一个大规模的访谈研究的方法和初步结果的3,824年轻的成年双胞胎（1972-1979年出生）和他们的兄弟姐妹。大麻的使用是常见的，75.2%的男性和64.7%的女性报告说一生中使用大麻，而24.5%的男性和11.8%的女性报告说符合DSM-IV大麻滥用或依赖的标准。其他药物使用障碍和常见精神疾病的发生率与大麻的参与程度高度相关，并且有一致的证据表明，在一系列大麻表型中，包括早期大麻表现型，（≤15年）使用机会（h2 = 72%），早期（≤16岁）发作使用（h2 = 80%），使用大麻11+次终身（h2 = 76%），DSM滥用/依赖（h2 = 72%）。开始使用大麻的年龄较早与后来使用其他非法药物的比率增加以及与非法药物滥用/依赖密切相关;进一步分析表明，这种关联的某些组成部分可能是由于接触其他非法药物和使用其他非法药物的机会增加而起作用的。
Cannabis is the most widely used illicit drug throughout the developed world and there is consistent evidence of heritable influences on multiple stages of cannabis involvement including initiation of use and abuse/dependence. In this paper, we describe the methodology and preliminary results of a large-scale interview study of 3,824 young adult twins (born 1972–1979) and their siblings. Cannabis use was common with 75.2% of males and 64.7% of females reporting some lifetime use of cannabis while 24.5% of males and 11.8% of females reported meeting criteria for DSM-IV cannabis abuse or dependence. Rates of other drug use disorders and common psychiatric conditions were highly correlated with extent of cannabis involvement and there was consistent evidence of heritable influences across a range of cannabis phenotypes including early (≤15 years) opportunity to use (h2 = 72%), early (≤16 years) onset use (h2 = 80%), using cannabis 11+ times lifetime (h2 = 76%), and DSM abuse/dependence (h2 = 72%). Early age of onset of cannabis use was strongly associated with increased rates of subsequent use of other illicit drugs and with illicit drug abuse/dependence; further analyses indicating that some component of this association may have been mediated by increasing exposure to and opportunity to use other illicit drugs.
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DOI：
10.1111/j.1467-842x.2000.tb01605.x
发表时间：
2000-08-01
影响因子：
3.5
作者：
Degenhardt, L;Lynskey, M;Hall, W
通讯作者：
Hall, W
影响因子：
6.9
作者：
Budney, AJ;Hughes, JR
通讯作者：
Hughes, JR
影响因子：
6.9
作者：
Hall, Wayne;Degenhardt, Louisa
通讯作者：
Degenhardt, Louisa
影响因子：
4.2
作者：
Kandel, DB;Huang, FY;Davies, M
通讯作者：
Davies, M
DOI：
10.1111/j.1530-0277.1999.tb04036.x
发表时间：
1999-01-01
影响因子：
3.2
作者：
Hasin, D;Paykin, A
通讯作者：
Paykin, A