Bidirectional effects of inhibiting or potentiating NMDA receptors on extinction after cocaine self-administration in rats.
Bidirectional effects of inhibiting or potentiating NMDA receptors on extinction after cocaine self-administration in rats.
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DOI：
10.1007/s00213-014-3607-1
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发表时间：
2014-12
影响因子：
3.4
通讯作者：
Mueller, Devin
中科院分区：
文献类型：
--
作者：
Hafenbreidel, Madalyn;Todd, Carolynn Rafa;Twining, Robert C.;Tuscher, Jennifer J.;Mueller, Devin
关键词：
Extinction of drug seeking is facilitated by NMDA receptor (NMDAr) agonists, but it remains unclear whether extinction is dependent on NMDAr activity. We investigated the necessity of NMDArs for extinction of cocaine seeking, and whether extinction altered NMDAr expression within extinction-related neuroanatomical loci. Rats were trained to lever press for i.v. infusions of cocaine or sucrose reinforcement prior to extinction training or withdrawal. Administration of the NMDAr competitive antagonist CPP prior to four brief extinction sessions impaired subsequent extinction retention. In contrast, post-extinction administration of the NMDAr coagonist D-serine attenuated lever pressing across days as compared to saline administration, indicative of facilitated consolidation of extinction. Furthermore, expression of the NMDAr subunits, GluN2A and GluN2B, was not altered in the ventromedial prefrontal cortex. However, both GluN2A and GluN2B subunit expression in the nucleus accumbens was increased following cocaine self-administration, and this increased expression was relatively resistant to modulation by extinction. Our findings demonstrate that extinction of cocaine seeking is bidirectionally mediated by NMDArs and suggest that selective modulation of NMDAr activity could facilitate extinction-based therapies for treatment of cocaine abuse.
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影响因子：
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作者：
Kelamangalath, L.;Wagner, J. J.
通讯作者：
Wagner, J. J.
影响因子：
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Hammond S;Seymour CM;Burger A;Wagner JJ
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Wagner JJ
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Ben-Shahar, Osnat;Obara, Ilona;Ary, Alexis W.;Ma, Natalie;Mangiardi, Mario A.;Medina, Robert L.;Szumlinski, Karen K.
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