Peripheral and Central Nutrient Sensing Underlying Appetite Regulation.

Peripheral and Central Nutrient Sensing Underlying Appetite Regulation.
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外围和中央营养感应的食欲调节。

DOI:
10.1016/j.tins.2018.05.003
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发表时间:
2018-08
影响因子:
15.9
通讯作者:
Oka Y
Oka Y
中科院分区:
医学1区
文献类型:
--
作者:
Augustine V;Gokce SK;Oka Y

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The precise regulation of fluid and energy homeostasis is essential for survival. It is well appreciated that ingestive behaviors are tightly regulated both by peripheral sensory inputs and central appetite signals. With recent neurogenetic technologies, considerable progress has been made in our understanding of basic taste qualities, the molecular/cellular basis of taste sensing, and the central circuits for thirst and hunger. In this review, we first highlight the functional similarities and differences between mammalian and invertebrate taste processing. We then discuss how central thirst and hunger signals interact with peripheral sensory signals to regulate ingestive behaviors. We finally indicate some of the directions for future research.
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