Detection of dynamic frequencies of Th17 cells and their associations with clinical parameters in patients with systemic lupus erythematosus receiving standard therapy
Detection of dynamic frequencies of Th17 cells and their associations with clinical parameters in patients with systemic lupus erythematosus receiving standard therapy
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接受标准治疗的系统性红斑狼疮患者Th17细胞动态频率检测及其与临床参数的关系
DOI：
10.1007/s10067-014-2656-5
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发表时间：
2014-05
影响因子：
3.4
通讯作者：
Xiong, Sidong
中科院分区：
文献类型：
--
作者：
Wen, Zhenke;Xu, Lin;Xu, Wei;Xiong, Sidong
近期证据表明Th17细胞在系统性红斑狼疮（SLE）的发病机制中起重要作用。然而，接受临床治疗的SLE患者中Th17细胞频率的动态变化与临床参数之间的关联（句子似乎不完整）
Recent evidence implicated an important role of Th17 cells in the pathogenesis of systemic lupus erythematosus (SLE). However, the association between dynamic changes of Th17 cell frequency and clinical parameters in SLE patients receiving clinical managements remains unknown. Here, we sought to evaluate their correlation in Chinese new-onset SLE patients with standard therapy. We found that the frequency of Th17 cells was higher in SLE patients than that in healthy controls and could be decreased by standard care. In consistent, the level of serum IL-6, IL-1β, IL-23, and Stat3 activity was elevated in SLE patients and down-regulated by disease treatment. Of note, the frequency of Th17 cells was correlated with SLEDAI and serum C3 in SLE patients. The changes of Th17 cell frequency were associated with those of SLEDAI and serum C3 in SLE patients between pretreatment and posttreatment. Further, the Th17 cell frequency was positively correlated with serum anti-dsDNA antibody in SLE patients. The changes of Th17 cell frequency were associated with those of serum anti-dsDNA antibody in SLE patients. Our findings showed that dynamic frequencies of Th17 cells were closely correlated with clinical parameters in SLE patients receiving standard treatment, which could facilitate the efficient management and development of novel therapeutics for SLE.
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影响因子：
4.3
作者：
Henriques, Ana;Ines, Luis;Paiva, Artur
通讯作者：
Paiva, Artur
影响因子：
30.5
作者：
Doreau, Agnes;Belot, Alexandre;Bonnefoy-Berard, Nathalie
通讯作者：
Bonnefoy-Berard, Nathalie
影响因子：
2.6
作者：
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通讯作者：
Lan, J-L
影响因子：
9.1
作者：
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通讯作者：
Xuyan Yang;Hui‐ying Wang;Xiao-ying Zhao;Lijuan Wang;Qing-hua Lv;Qing-qing Wang
影响因子：
4.4
作者：
Kang, Hee-Kap;Liu, Michael;Datta, Syamal K.
通讯作者：
Datta, Syamal K.