T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival.
T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival.
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DOI：
10.1371/journal.pone.0024972
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
David M
中科院分区：
文献类型：
--
作者：
Moro H;Otero DC;Tanabe Y;David M
STAT1 is an essential part of interferon signaling, and STAT1-deficiency results in heightened susceptibility to infections or autoimmunity in both mice and humans. Here we report that mice lacking the IFNα/β-receptor (IFNAR1) or STAT1 display impaired deletion of autoreactive CD4+CD8+-T-cells. Strikingly, co-existence of WT T cells restored thymic elimination of self-reactive STAT1-deficient CD4+CD8+-T cells. Analysis of STAT1-deficient thymocytes further revealed reduced Bim expression, which was restored in the presence of WT T cells. These results indicate that type I interferons and STAT1 play an important role in the survival of MHC class I-restricted T cells in a T cell intrinsic and non-cell intrinsic manner that involves regulation of Bim expression through feedback provided by mature STAT1-competent T cells.
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影响因子：
64.5
作者：
LAFAILLE, JJ;NAGASHIMA, K;TONEGAWA, S
通讯作者：
TONEGAWA, S
影响因子：
64.8
作者：
MOMBAERTS, P;CLARKE, AR;TONEGAWA, S
通讯作者：
TONEGAWA, S
DOI：
10.1016/s0167-5699(99)01541-8
发表时间：
2000-01-01
期刊：
IMMUNOLOGY TODAY
影响因子：
--
作者：
Karp, CL;Biron, CA;Irani, DN
通讯作者：
Irani, DN
影响因子：
32.4
作者：
Choi, EY;Jung, KC;Park, SH
通讯作者：
Park, SH
影响因子：
56.9
作者：
HUANG, S;HENDRIKS, W;AGUET, M
通讯作者：
AGUET, M