Covarying alterations in Aβ deposition, glucose metabolism, and gray matter volume in cognitively normal elderly.
Covarying alterations in Aβ deposition, glucose metabolism, and gray matter volume in cognitively normal elderly.
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DOI：
10.1002/hbm.22173
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发表时间：
2014-01
影响因子：
4.8
通讯作者：
Jagust, William
中科院分区：
文献类型：
--
作者：
Oh, Hwamee;Habeck, Christian;Madison, Cindee;Jagust, William
阿尔茨海默病(β-β，A-A)是阿尔茨海默病(AD)的一个病理特征，可能先于AD患者糖代谢和灰质体积的减少和认知能力的下降。然而，在认知正常的老年人中也有Aβ积聚的报道，尽管在认知正常的老年人中Aβ沉积、葡萄糖代谢和灰质体积是否以及如何相互关联仍未确定。52名认知正常的老年人接受了匹兹堡化合物B正电子发射断层扫描(PIB-PET)、[18F]氟脱氧葡萄糖(FDG)PET和结构磁共振(MRI)成像，分别测量了全脑淀粉样蛋白沉积、葡萄糖代谢和灰质体积。使用基于主成分分析的多变量方法提取这些测量与PIB指数测量的全球淀粉样蛋白负荷相关的协方差模式。较高的整体淀粉样蛋白负荷与淀粉样蛋白沉积和葡萄糖代谢的相对增加以及大脑区域中灰质体积的相对减少有关，这些区域统称为默认模式网络，包括后扣带/楔前叶、外顶叶皮质和额叶内侧皮质。外侧前额叶皮质淀粉样蛋白沉积和葡萄糖代谢相对增加，海马区灰质体积相对减少。当控制年龄、性别和教育程度时，PIB数据的地形模式的表达程度与视觉记忆表现进一步相关。目前的研究结果表明，认知正常、淀粉样蛋白沉积较多的老年人在额叶和顶叶脑区相对高代谢，而在重叠的脑区灰质体积减少。
β-amyloid (Aβ), a feature of Alzheimer’s disease (AD) pathology, may precede reduced glucose metabolism and gray matter volume and cognitive decline in AD patients. Accumulation of Aβ, however, has been also reported in cognitively intact older people, although it remains unresolved whether and how Aβ deposition, glucose metabolism, and gray matter volume relate to one another in cognitively normal elderly. Fifty-two cognitively normal older adults underwent Pittsburgh Compound B positron emission tomography (PIB-PET), [18F]fluorodeoxyglucose (FDG) PET, and structural magnetic resonance (MRI) imaging to measure whole brain amyloid deposition, glucose metabolism, and gray matter volume, respectively. Covariance patterns of these measures in association with global amyloid burden measured by PIB index were extracted using principal component analysis-based multivariate methods. Higher global amyloid burden was associated with relative increases of amyloid deposition and glucose metabolism and relative decreases of gray matter volume in brain regions collectively known as the default mode network including the posterior cingulate/precuneus, lateral parietal cortices, and medial frontal cortex. Relative increases of amyloid deposition and glucose metabolism were also noted in the lateral prefrontal cortices, and relative decreases of gray matter volume were pronounced in hippocampus. The degree of expression of the topographical patterns of the PIB data was further associated with visual memory performance when controlling for age, sex, and education. The present findings suggest that cognitively normal older adults with greater amyloid deposition are relatively hypermetabolic in frontal and parietal brain regions while undergoing gray matter volume loss in overlapping brain regions.
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影响因子：
3.7
作者：
Dickerson, Bradford C.;Bakkour, Akram;Salat, David H.;Feczko, Eric;Pacheco, Jenni;Greve, Douglas N.;Grodstein, Fran;Wright, Christopher I.;Blacker, Deborah;Rosas, H. Diana;Sperling, Reisa A.;Atri, Alireza;Growdon, John H.;Hyman, Bradley T.;Morris, John C.;Fischl, Bruce;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
基础大脑代谢可能会调节Abeta在轻度认知障碍中的认知作用：大脑储备的一个例子。
DOI：
10.1523/jneurosci.3669-09.2009
发表时间：
2009-11-25
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cohen AD;Price JC;Weissfeld LA;James J;Rosario BL;Bi W;Nebes RD;Saxton JA;Snitz BE;Aizenstein HA;Wolk DA;Dekosky ST;Mathis CA;Klunk WE
通讯作者：
Klunk WE
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
--
作者：
Aizenstein, Howard Jay;Nebes, Robert D.;Saxton, Judith A.;Price, Julie C.;Mathis, Chester A.;Tsopelas, Nicholas D.;Ziolko, Scott K.;James, Jeffrey A.;Snitz, Beth E.;Houck, Patricia R.;Bi, Wenzhu;Cohen, Ann D.;Lopresti, Brian J.;DeKosky, Steven T.;Halligan, Edythe M.;Klunk, William E.
通讯作者：
Klunk, William E.
影响因子：
9.9
作者：
Dickerson, BC;Salat, DH;Sperling, RA
通讯作者：
Sperling, RA