Measuring cognitive function in MDD: emerging assessment tools.
Measuring cognitive function in MDD: emerging assessment tools.
复制标题
DOI：
10.1002/da.22297
复制
发表时间：
2015-04
影响因子：
7.4
通讯作者：
Burdick, Katherine E.
中科院分区：
文献类型：
--
作者：
Russo, Manuela;Mahon, Katie;Burdick, Katherine E.
认知障碍正在成为包括重度抑郁症（MDD）在内的精神疾病患者的重要治疗目标。本综述的目的是简要回顾MDD认知功能障碍的证据，并总结目前可用于评估抑郁症患者认知功能的认知评估工具的代表性样本。在认知功能障碍的MDD患者中的研究结果有些不一致，可能是由于疾病的异质性以及使用不同的评估工具。测量这一人群的认知变化具有挑战性。认知症状通常没有精神分裂症和双相情感障碍患者严重，需要比现有工具更高的灵敏度。初步证据表明，抗抑郁治疗可能会改善认知功能，这是改善抑郁症状的直接结果;然而，任何促认知作用尚未阐明。为了评价抗抑郁药对伴有认知功能障碍的MDD患者的疗效，在临床试验中使用标准化认知成套测验是必不可少的。
Cognitive impairment is emerging as an important therapeutic target in patients with psychiatric illnesses, including major depressive disorder (MDD). The objective of this general overview is to briefly review the evidence for cognitive impairment in MDD and to summarize a representative sample of cognitive assessment tools currently available to assess cognitive function in depressed patients. Study results in MDD patients with cognitive dysfunction are somewhat inconsistent, likely due to the heterogeneity of the disorder as well as the use of diverse assessment tools. Measuring cognitive changes in this population is challenging. Cognitive symptoms are typically less severe than in patients with schizophrenia and bipolar disorder, requiring greater sensitivity than afforded by existing tools. Preliminary evidence suggests antidepressant treatments may improve cognitive functioning as a direct result of ameliorating depressive symptoms; however, any procognitive effects have not been elucidated. To evaluate antidepressant efficacy in MDD patients with cognitive dysfunction, a standardized cognitive battery for use in clinical trials is essential.
登录
查看更多内容
影响因子：
11.3
作者：
Ladegaard, Nicolai;Larsen, Erik Roj;Lysaker, Paul H.
通讯作者：
Lysaker, Paul H.
影响因子：
6.9
作者：
Kessing, LV
通讯作者：
Kessing, LV
影响因子：
2.4
作者：
Hasselbalch, Bo Jacob;Knorr, Ulla;Kessing, Lars Vedel
通讯作者：
Kessing, Lars Vedel
影响因子：
4.8
作者：
Herrera-Guzman, Ixchel;Gudayol-Ferre, Esteve;Herrera-Abarca, Jorge E.
通讯作者：
Herrera-Abarca, Jorge E.
影响因子：
3.9
作者：
Dziobek, Isabel;Fleck, Stefan;Convit, Antonio
通讯作者：
Convit, Antonio