Decreased auditory GABA+ concentrations in presbycusis demonstrated by edited magnetic resonance spectroscopy.
Decreased auditory GABA+ concentrations in presbycusis demonstrated by edited magnetic resonance spectroscopy.
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DOI：
10.1016/j.neuroimage.2014.11.023
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发表时间：
2015-02-01
期刊：
影响因子：
5.7
通讯作者：
Edden RA
中科院分区：
文献类型：
--
作者：
Gao F;Wang G;Ma W;Ren F;Li M;Dong Y;Liu C;Liu B;Bai X;Zhao B;Edden RA
γ-氨基丁酸（GABA）是中枢听觉系统中主要的抑制性神经递质。在老年性耳聋动物模型的下丘和听觉皮层中都发现了 GABA 能神经传递的改变。使用 MEGA-PRESS 序列的编辑磁共振波谱 (MRS) 是检测人脑中 GABA 的最广泛使用的技术。然而，迄今为止，很少有研究探索老年性耳聋患者听觉区 GABA 浓度的变化。在这项研究中，16 名老年性耳聋患者（5 名男性/11 名女性，平均年龄 63.1 ± 2.6 岁）和 20 名健康对照者（6 名男性/14 名女性，平均年龄 62.5 ± 2.3 岁）接受了听力学和 MRS 检查。使用 0.125 至 8 KHz 的纯音测听和鼓室导抗测试来评估所有受试者的听力能力。计算纯音平均值（PTA；0.5、1、2 和 4 kHz 听阈的平均值）。 MEGA-PRESS 序列用于测量以左右 Heschl 回为中心的 4 × 3 × 3 cm3 体积中的 GABA+ 浓度。与对照组相比，老年性耳聋组的 GABA+ 浓度显着降低（左听觉区域：p = 0.002，右听觉区域：p = 0.008）。在老年性耳聋组中，PTA 和 GABA+ 浓度之间观察到显着的负相关性（r = -0.57，p = 0.02），而在对照组中也发现了类似的趋势（r = -0.40，p = 0.08）。这些结果与老年性耳聋中枢听觉系统中 GABA 能神经传递功能失调的假设一致，并提出了老年性耳聋的潜在治疗目标。
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the central auditory system. Altered GABAergic neurotransmission has been found in both the inferior colliculus and the auditory cortex in animal models of presbycusis. Edited magnetic resonance spectroscopy (MRS), using the MEGA-PRESS sequence, is the most widely used technique for detecting GABA in the human brain. However, to date there has been a paucity of studies exploring changes to the GABA concentrations in the auditory region of patients with presbycusis. In this study, sixteen patients with presbycusis (5 males/11 females, mean age 63.1 ± 2.6 years) and twenty healthy controls (6 males/14 females, mean age 62.5 ± 2.3 years) underwent audiological and MRS examinations. Pure tone audiometry from 0.125 to 8 KHz and tympanometry were used to assess the hearing abilities of all subjects. The pure tone average (PTA; the average of hearing thresholds at 0.5, 1, 2, and 4 kHz) was calculated. The MEGA-PRESS sequence was used to measure GABA+ concentrations in 4 × 3 × 3 cm3 volumes centered on the left and right Heschl’s gyri. GABA+ concentrations were significantly lower in the presbycusis group compared to the control group (left auditory regions: p = 0.002, right auditory regions: p = 0.008). Significant negative correlations were observed between PTA and GABA+ concentrations in the presbycusis group (r = −0.57, p = 0.02), while a similar trend was found in the control group (r = −0.40, p = 0.08). These results are consistent with a hypothesis of dysfunctional GABAergic neurotransmission in the central auditory system in presbycusis, and suggest a potential treatment target for presbycusis.
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影响因子：
3.9
作者：
CASPARY, DM;MILBRANDT, JC;HELFERT, RH
通讯作者：
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