Carotid Intima-Media Roughness and Elasticity in Hypertensive Patients With Normal Carotid Intima-Media Thickness.
Carotid Intima-Media Roughness and Elasticity in Hypertensive Patients With Normal Carotid Intima-Media Thickness.
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颈动脉内膜中层厚度正常的高血压患者的颈动脉内膜中层粗糙度和弹性
DOI：
10.1002/jum.14843
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发表时间：
2019-06
期刊：
影响因子：
--
通讯作者：
Lv Q
中科院分区：
文献类型：
--
作者：
Wu Y;Xie M;Zhang L;Lu X;Cheng X;Lv Q
采用自动识别软件研究颈动脉内膜中层厚度（IMT）正常的高血压患者的颈动脉内膜中层粗糙度（IMR）及其与危险因素的相关性。该病例对照研究包括61名颈动脉IMT正常的高血压患者和51名对照参与者。使用自动识别程序和回声跟踪分析软件，通过颈动脉超声和图像后处理确定颈动脉IMR、颈动脉IMT、脉搏波速度（PWV）、硬度（β）和动脉顺应性。高血压组颈动脉IMR、平均颈动脉IMT、最大颈动脉IMT、β、PWV均高于对照组（58.24对34.61 μm，641.17对576.48 μm，746.82对640.55 μm，9.42对7.35，7.10对5.86 m/s）;动脉顺应性低于对照组（0.70与0.95 mm 2/kPa; P <0.05）。内膜-中膜粗糙度与最大IMT、平均IMT、PWV、β、年龄、诊断为高血压超过1年和脉压相关。多因素Logistic回归分析显示，年龄、高血压病史> 1年、脉压是高血压患者IMR的影响因素，OR值为6.719（95%置信区间，1.658-27.221; P = .008），4.726（95%置信区间，1.174-19.022; P = .029）和3.998（95%置信区间，1.033-15.466; P = .045）。颈动脉IMR和弹性指数在评估高血压人群早期动脉粥样硬化风险方面具有重要的临床意义。
To investigate carotid intima‐media roughness (IMR) in hypertensive patients with normal carotid intima‐media thickness (IMT) using automatic identification software and the correlation between carotid IMR and risk factors. This case‐control study comprised 61 hypertensive patients with normal carotid IMT and 51 control participants. Carotid IMR, carotid IMT, pulsed wave velocity (PWV), stiffness (β), and arterial compliance were determined by carotid ultrasound and image postprocessing using an automatic identification program and echo‐tracking analysis software. Carotid IMR, mean carotid IMT, maximum carotid IMT, β, and PWV in the hypertension group were higher than those in the control group (58.24 versus 34.61 μm, 641.17 versus 576.48 μm, 746.82 versus 640.55 μm, 9.42 versus 7.35, and 7.10 versus 5.86 m/s, respectively; P < .05), and arterial compliance was lower than that in the control group (0.70 versus 0.95 mm2/kPa; P < .05). Intima‐media roughness was correlated with maximum IMT, mean IMT, PWV, β, age, diagnosis of hypertension for greater than 1 year, and pulse pressure. Multivariate logistic regression showed that age, diagnosis of hypertension for greater than 1 year, and pulse pressure were influential factors for IMR in hypertensive patients, with odds ratios of 6.719 (95% confidence interval, 1.658–27.221; P = .008), 4.726 (95% confidence interval, 1.174–19.022; P = .029), and 3.998 (95% confidence interval, 1.033–15.466; P = .045), respectively. Carotid IMR and the elasticity index have important clinical importance in evaluating the risk of early atherosclerosis in hypertensive populations.
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5.6
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