Towards evolution-proof malaria control with insecticides.
Towards evolution-proof malaria control with insecticides.
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DOI：
10.1111/j.1752-4571.2009.00072.x
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发表时间：
2009-11
影响因子：
4.1
通讯作者：
Read AF
中科院分区：
文献类型：
--
作者：
Koella JC;Lynch PA;Thomas MB;Read AF
由于许多控制疟疾的策略使用杀虫剂来对付成年蚊子，因此控制受到抗药性蚊子不断进化的破坏。在这里，我们建议使用替代杀虫剂，或以替代方式使用常规杀虫剂可能会有效控制，但会大大延迟或阻止抗性的演变。我们的推理依赖于流行病学和进化原理：（1）疟疾的流行病学受到蚊子寿命的强烈影响，因为大多数受感染的蚊子在疟原虫完成发育之前就死亡了;（2）进化压力在年轻个体中最强，因为选择已经完成大部分繁殖的个体几乎没有进化影响。从这些原则可以得出：第一，在接触杀虫剂几天后杀死蚊子的杀虫剂可以大大推迟抗药性的演变;第二，对杀幼虫剂的抗药性的演变实际上可以有利于控制，如果它与寿命缩短或减少成虫的叮咬有关。如果将迟效杀虫剂和杀幼虫剂结合使用，在某些情况下，对杀幼虫剂的抗药性的演变可以防止对更有效的迟效杀虫剂的抗药性的演变，从而实现可持续的有效控制。我们讨论了几个潜在的选择，创造这样的杀虫剂，重点是生物农药。
As many strategies to control malaria use insecticides against adult mosquitoes, control is undermined by the continual evolution of resistant mosquitoes. Here we suggest that using alternative insecticides, or conventional insecticides in alternative ways might enable effective control, but delay considerably or prevent the evolution of resistance. Our reasoning relies on an epidemiological and an evolutionary principle: (i) the epidemiology of malaria is strongly influenced by the life-span of mosquitoes, as most infected mosquitoes die before the malaria parasite has completed its development; and (ii) evolutionary pressure is strongest in young individuals, for selection on individuals that have completed most of their reproduction has little evolutionary effect. It follows from these principles, first, that insecticides that kill mosquitoes several days after exposure can delay considerably the evolution of resistance and, second, that the evolution of resistance against larvicides can actually benefit control, if it is associated with shorter life-span or reduced biting in adults. If a late-acting insecticide and a larvicide are combined, the evolution of resistance against larvicides can in some circumstances prevent the evolution of resistance against the more effective, late-acting insecticide, leading to sustainable, effective control. We discuss several potential options to create such insecticides, focussing on biopesticides.
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影响因子：
2
作者：
HAMILTON, WD
通讯作者：
HAMILTON, WD
影响因子：
1.9
作者：
Hunt, RH;Brooke, BD;Coetzee, M
通讯作者：
Coetzee, M
DOI：
10.1098/rstb.1998.0329
发表时间：
1998-10-29
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
Curtis, CF;Miller, JE;Kasumba, I
通讯作者：
Kasumba, I
影响因子：
4.8
作者：
HAWLEY, WA
通讯作者：
HAWLEY, WA
影响因子：
3.7
作者：
Bargielowski I;Koella JC
通讯作者：
Koella JC