Functional connectivity and gray matter deficits within the auditory attention circuit in first-episode psychosis.
Functional connectivity and gray matter deficits within the auditory attention circuit in first-episode psychosis.
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DOI：
10.3389/fpsyt.2023.1114703
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发表时间：
2023
影响因子：
4.7
通讯作者：
Salisbury, Dean F.
中科院分区：
文献类型：
--
作者：
Curtis, Mark T.;Sklar, Alfredo L.;Coffman, Brian A.;Salisbury, Dean F.
关键词：
精神病首次发作（FEP）的选择性注意缺陷可以通过听觉M100的注意调制受损来指示。目前尚不清楚这种缺陷的病理生理学是否仅限于听觉皮层或涉及分布式注意力网络。我们研究了FEP中的听觉注意网络。MEG记录从27 FEP和31匹配的健康对照（HC），而交替忽略或注意的音调。听觉M100期间MEG源活动的全脑分析确定了活动增加的非听觉区域。通过检测听觉皮层的时频活动和相幅耦合来确定注意执行载波频率。注意力网络是通过载波频率的锁相来定义的。在FEP中检查了所识别回路中的光谱和灰质缺陷。注意力相关的活动被确定在前额叶和顶叶区域，显着楔前叶。在左侧初级听觉皮层，θ功率和γ振幅的相位耦合随着注意力的增加而增加。两个单侧注意网络被确定与楔前叶种子在HC。FEP中的网络同步性受损。在FEP中，左半球网络内的灰质厚度减少，但与同步性无关。几个额外的听觉注意领域的注意相关的活动被确定。θ是听觉皮层注意调制的载波频率。左右半球的注意网络被确定，双边功能缺陷和左半球的结构缺陷，虽然FEP显示完整的听觉皮层θ相位-γ振幅耦合。这些新的发现表明，精神病早期的注意力相关回路病可能适合未来的非侵入性干预。
Selective attention deficits in first episode of psychosis (FEP) can be indexed by impaired attentional modulation of auditory M100. It is unknown if the pathophysiology underlying this deficit is restricted to auditory cortex or involves a distributed attention network. We examined the auditory attention network in FEP. MEG was recorded from 27 FEP and 31 matched healthy controls (HC) while alternately ignoring or attending tones. A whole-brain analysis of MEG source activity during auditory M100 identified non-auditory areas with increased activity. Time-frequency activity and phase-amplitude coupling were examined in auditory cortex to identify the attentional executive carrier frequency. Attention networks were defined by phase-locking at the carrier frequency. Spectral and gray matter deficits in the identified circuits were examined in FEP. Attention-related activity was identified in prefrontal and parietal regions, markedly in precuneus. Theta power and phase coupling to gamma amplitude increased with attention in left primary auditory cortex. Two unilateral attention networks were identified with precuneus seeds in HC. Network synchrony was impaired in FEP. Gray matter thickness was reduced within the left hemisphere network in FEP but did not correlate with synchrony. Several extra-auditory attention areas with attention-related activity were identified. Theta was the carrier frequency for attentional modulation in auditory cortex. Left and right hemisphere attention networks were identified, with bilateral functional deficits and left hemisphere structural deficits, though FEP showed intact auditory cortex theta phase-gamma amplitude coupling. These novel findings indicate attention-related circuitopathy early in psychosis potentially amenable to future non-invasive interventions.
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影响因子：
3.7
作者：
Cho, Raymond Y.;Walker, Christopher P.;Lewis, David A.
通讯作者：
Lewis, David A.
DOI：
10.1073/pnas.0609440103
发表时间：
2006-12-26
影响因子：
11.1
作者：
Cho, R. Y.;Konecky, R. O.;Carter, C. S.
通讯作者：
Carter, C. S.
影响因子：
6.6
作者：
Cornblatt, BA;Lencz, T;Nakayama, E
通讯作者：
Nakayama, E
影响因子：
3.7
作者：
Dreher JC;Koechlin E;Tierney M;Grafman J
通讯作者：
Grafman J
影响因子：
2.9
作者：
Alho, K;Vorobyev, VA;Näätänen, R
通讯作者：
Näätänen, R