Population ancestry and genetic risk for diabetes and kidney, cardiovascular, and bone disease: modifiable environmental factors may produce the cures.
Population ancestry and genetic risk for diabetes and kidney, cardiovascular, and bone disease: modifiable environmental factors may produce the cures.
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DOI：
10.1053/j.ajkd.2013.05.024
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Palmer ND
中科院分区：
文献类型：
--
作者：
Freedman BI;Divers J;Palmer ND
在不同大陆人口群体成员之间观察到的不同疾病率可能由遗传因素、环境暴露或其组合介导。这份手稿提供的证据支持差异等位基因频率分布的基础上的局灶节段性肾小球硬化疾病谱的非糖尿病肾病和冠状动脉钙化动脉粥样硬化斑块和骨质疏松症的非洲血统的人群的发病率较低。随着认识到这些和其他常见的复杂疾病受生物因素的影响，人们意识到环境暴露和药物治疗的靶向操作将根据基因型产生不同的影响。当前的精准医学时代将把一个人的基因组成与特定的疗法结合起来，以减少基于疾病特异性等位基因的疾病发生率。
Variable rates of disease observed between members of different continental population groups may be mediated by inherited factors, environmental exposures, or their combination. This manuscript provides evidence in support of differential allele frequency distributions that underlie the higher rates of non-diabetic kidney disease in the focal segmental glomerulosclerosis spectrum of disease and lower rates of coronary artery calcified atherosclerotic plaque and osteoporosis in populations of African ancestry. With recognition that these and other common complex diseases are affected by biologic factors comes the realization that targeted manipulation of environmental exposures and pharmacologic treatments will have different effects based on genotype. The current era of precision medicine will couple one’s genetic make-up with specific therapies to reduce rates of disease based on presence of disease-specific alleles.
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DOI：
10.2215/cjn.08721209
发表时间：
2010-06
期刊：
Clinical journal of the American Society of Nephrology : CJASN
影响因子：
--
作者：
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通讯作者：
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DOI：
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发表时间：
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期刊：
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影响因子：
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