Characterization of the Sexually Dimorphic fruitless Neurons That Regulate Copulation Duration.

Characterization of the Sexually Dimorphic fruitless Neurons That Regulate Copulation Duration.
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DOI:
10.3389/fphys.2018.00780
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发表时间:
2018
影响因子:
4
通讯作者:
Leung AK
Leung AK
中科院分区:
医学2区
文献类型:
--
作者:
Jois S;Chan YB;Fernandez MP;Leung AK

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果蝇的雄性求偶行为是一种先天性的两性异形行为,这种行为在神经系统中是固定的。了解求偶行为的神经机制需要所有相关神经元的解剖和功能特征。求偶涉及一系列独特的行为模式,最终在最后的交配步骤,精子从男性转移到女性。这一过程的持续时间由多个基因严格控制。fru基因是调控交配持续时间的因子之一。使用几个交叉的遗传组合,以限制标记的GAL4线,我们发现,一个子集的一个神经元簇的fru神经元共表达多巴胺合成酶,酪氨酸羟化酶,并提供行为和免疫学证据,这些神经元参与调节交配持续时间。
Male courtship in Drosophila melanogaster is a sexually dimorphic innate behavior that is hardwired in the nervous system. Understanding the neural mechanism of courtship behavior requires the anatomical and functional characterization of all the neurons involved. Courtship involves a series of distinctive behavioral patterns, culminating in the final copulation step, where sperms from the male are transferred to the female. The duration of this process is tightly controlled by multiple genes. The fruitless (fru) gene is one of the factors that regulate the duration of copulation. Using several intersectional genetic combinations to restrict the labeling of GAL4 lines, we found that a subset of a serotonergic cluster of fru neurons co-express the dopamine-synthesizing enzyme, tyrosine hydroxylase, and provide behavioral and immunological evidence that these neurons are involved in the regulation of copulation duration.
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