Duffy blood group gene polymorphisms among malaria vivax patients in four areas of the Brazilian Amazon region.
Duffy blood group gene polymorphisms among malaria vivax patients in four areas of the Brazilian Amazon region.
复制标题
巴西亚马逊地区四个地区的疟疾疟疾患者的达菲血型基因多态性。
DOI：
10.1186/1475-2875-6-167
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发表时间：
2007-12-19
期刊：
影响因子：
3
通讯作者：
Machado RL
中科院分区：
文献类型：
--
作者：
Cavasini CE;de Mattos LC;Couto AA;Couto VS;Gollino Y;Moretti LJ;Bonini-Domingos CR;Rossit AR;Castilho L;Machado RL
达菲血型多态性在间日疟原虫占主导地位的地区很重要，因为这种分子充当这种原生动物的受体。本研究报道了巴西4个不同流行区间日疟原虫疟疾患者的Duffy血型基因分型，探讨了血型变异与疟疾易感性或耐药性之间的显著关联。间日疟原虫鉴定采用非基因型和基因型筛选试验。采用PCR/RFLP对来自巴西亚马逊地区的330名献血者和312名疟疾患者进行了Duffy血型基因分型。为了评估各变量的显著性和各比例之间的独立性，采用Fisher精确检验。数据显示，FYA/FYB基因型频率最高，其次是FYB/FYB、FYA/FYA、FYA/FYB-33和FYB/FYB-33。FYA/FYX、FYB/FYX、FYX/FYX和FYB-33/FYB-33基因型检测频率较低。两组中均发现达菲基因型阴性（FYB-33/FYB-33）：感染者和非感染者（献血者）。没有个体携带FYX/FYB-33基因型。一些达菲基因型频率在捐赠者和疟疾患者之间显示出显著差异。获得的数据表明，FYA/FYB基因型个体对疟疾具有更高的易感性。FYB-33等位基因的存在可能是种群中的一种选择优势，降低了该地区间日疟原虫的感染率。进一步的努力可能有助于更好地阐明间日疟原虫疟疾流行地区，特别是巴西亚马逊地区这种寄生虫/宿主关系的生理病理差异。
Duffy blood group polymorphisms are important in areas where Plasmodium vivax predominates, because this molecule acts as a receptor for this protozoan. In the present study, Duffy blood group genotyping in P. vivax malaria patients from four different Brazilian endemic areas is reported, exploring significant associations between blood group variants and susceptibility or resistance to malaria. The P. vivax identification was determined by non-genotypic and genotypic screening tests. The Duffy blood group was genotyped by PCR/RFLP in 330 blood donors and 312 malaria patients from four Brazilian Amazon areas. In order to assess the variables significance and to obtain independence among the proportions, the Fisher's exact test was used. The data show a high frequency of the FYA/FYB genotype, followed by FYB/FYB, FYA/FYA, FYA/FYB-33 and FYB/FYB-33. Low frequencies were detected for the FYA/FYX, FYB/FYX, FYX/FYX and FYB-33/FYB-33 genotypes. Negative Duffy genotype (FYB-33/FYB-33) was found in both groups: individuals infected and non-infected (blood donors). No individual carried the FYX/FYB-33 genotype. Some of the Duffy genotypes frequencies showed significant differences between donors and malaria patients. The obtained data suggest that individuals with the FYA/FYB genotype have higher susceptibility to malaria. The presence of the FYB-33 allele may be a selective advantage in the population, reducing the rate of infection by P. vivax in this region. Additional efforts may contribute to better elucidate the physiopathologic differences in this parasite/host relationship in regions endemic for P. vivax malaria, in particular the Brazilian Amazon region.
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影响因子：
9.8
作者：
Alves-Silva, J;Santos, MD;Prado, VF
通讯作者：
Prado, VF
影响因子：
--
作者：
Cavasini, Carlos Eugenio;De Mattos, Luiz Carlos;Dantas Machado, Ricardo Luiz
通讯作者：
Dantas Machado, Ricardo Luiz
DOI：
10.4269/ajtmh.2002.66.641
发表时间：
2002-06-01
影响因子：
3.3
作者：
Alves, FP;Durlacher, RR;Camargo, EP
通讯作者：
Camargo, EP
DOI：
10.1590/s0074-02762003000400004
发表时间：
2003-06-01
期刊：
Memórias do Instituto Oswaldo Cruz
影响因子：
--
作者：
Beiguelman, B;Alves, FP;Krieger, H
通讯作者：
Krieger, H
影响因子：
2.7
作者：
Ansart-Pirenne, H.;Martin-Blanc, S.;Tournamille, C.
通讯作者：
Tournamille, C.