Glucose metabolism during rotational shift-work in healthcare workers.
Glucose metabolism during rotational shift-work in healthcare workers.
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DOI：
10.1007/s00125-017-4317-0
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发表时间：
2017-08
期刊：
影响因子：
8.2
通讯作者：
Vella A
中科院分区：
文献类型：
--
作者：
Sharma A;Laurenti MC;Dalla Man C;Varghese RT;Cobelli C;Rizza RA;Matveyenko A;Vella A
倒班工作与昼夜节律紊乱、肥胖和2型糖尿病风险增加有关。我们试图确定轮班工作对人类葡萄糖代谢的影响。我们采用随机交叉研究设计对12名轮班工作的健康护士进行了研究。每次，参与者在模拟白班和模拟夜班期间进行同位素标记的混合餐测试，使用口服最小模型同时测量葡萄糖通量和β细胞功能。我们试图确定白班与夜班期间空腹和餐后葡萄糖代谢的差异。夜班期间餐后血糖漂移较高（381±33 vs 580±48 mmol/l / 5 h, p<0.01）。由于进食，胰岛素和c肽的峰值和胰高血糖素抑制的最低点也在夜班期间延迟。虽然胰岛素作用在研究期间没有差异，但β细胞对葡萄糖的反应性（59±5 vs 44±4 × 10−9 min−1;p<0.001）和处置指数在夜班期间下降。夜班期间β细胞功能受损可能是由于正常的昼夜节律变化、轮班工作的影响或两者的结合造成的。因此，在夜班期间观察到较高的餐后葡萄糖浓度。
Shift-work is associated with circadian rhythm disruption and an increased risk of obesity and type 2 diabetes. We sought to determine the effect of rotational shift-work on glucose metabolism in humans. We studied 12 otherwise healthy nurses performing rotational shift-work using a randomised crossover study design. On each occasion, participants underwent an isotope-labelled mixed meal test during a simulated day shift and a simulated night shift, enabling simultaneous measurement of glucose flux and beta cell function using the oral minimal model. We sought to determine differences in fasting and postprandial glucose metabolism during the day shift vs the night shift. Postprandial glycaemic excursion was higher during the night shift (381±33 vs 580±48 mmol/l per 5 h, p<0.01). The time to peak insulin and C-peptide and nadir glucagon suppression in response to meal ingestion was also delayed during the night shift. While insulin action did not differ between study days, the beta cell responsivity to glucose (59±5 vs 44±4 × 10−9 min−1; p<0.001) and disposition index were decreased during the night shift. Impaired beta cell function during the night shift may result from normal circadian variation, the effect of rotational shift-work or a combination of both. As a consequence, higher postprandial glucose concentrations are observed during the night shift.
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DOI：
10.1016/j.tem.2016.03.005
发表时间：
2016-05
期刊：
Trends in endocrinology and metabolism: TEM
影响因子：
--
作者：
Qian J;Scheer FAJL
通讯作者：
Scheer FAJL
DOI：
10.1073/pnas.0808180106
发表时间：
2009-03-17
影响因子：
11.1
作者：
Scheer, Frank A. J. L.;Hilton, Michael F.;Shea, Steven A.
通讯作者：
Shea, Steven A.
DOI：
10.1152/ajpendo.1996.271.2.e246
发表时间：
1996-08-01
影响因子：
5.1
作者：
Boden, G;Ruiz, J;Chen, XH
通讯作者：
Chen, XH
昼夜节律的代谢和能量学的融合。
DOI：
10.1126/science.1195027
发表时间：
2010-12-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bass J;Takahashi JS
通讯作者：
Takahashi JS
影响因子：
3.2
作者：
Bock, Gerlies;Man, Chiara Dalla;Vella, Adrian
通讯作者：
Vella, Adrian