Single-nucleotide polymorphisms reveal patterns of allele sharing across the species boundary between rhesus (Macaca mulatta) and cynomolgus (M. fascicularis) macaques.
Single-nucleotide polymorphisms reveal patterns of allele sharing across the species boundary between rhesus (Macaca mulatta) and cynomolgus (M. fascicularis) macaques.
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DOI：
10.1002/ajp.22091
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发表时间：
2013-02
影响因子：
2.4
通讯作者：
Kanthaswamy, Sree
中科院分区：
文献类型：
--
作者：
Trask, Jessica A. Satkoski;Garnica, Wendy T.;Smith, David Glenn;Houghton, Paul;Lerche, Nicholas;Kanthaswamy, Sree
在印度支那地区，人们观察到恒河猴（Macaca mulatta）和食蟹猴（Macaca fascicularis）之间不对称杂交的表型和遗传证据，因为这两个物种是同域的。在这一地区的两个物种之间的MHC II类等位基因的大规模共享支持的假设，基因，特别是参与免疫反应的基因，被转移跨越物种边界。这种差异渐渗具有重要的意义，将未知地理来源的食蟹猴纳入生物医学研究方案。我们的研究发现，对于2808个SNP标记，MAF和观察到的杂合性计算从一个样本的越南食蟹猴是显着不同的中国恒河猴和印尼食蟹猴的样本计算。来自中国恒河猴的SNP等位基因在越南食蟹猴样本中相对于其印度尼西亚同种的代表性过高，并且位于与初级免疫系统功能相关的基因中。这些结果表明，印度支那食蟹猴代表了一个遗传和免疫学不同的实体从印度尼西亚食蟹猴。
Both phenotypic and genetic evidence for asymmetric hybridization between rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques has been observed in the region of Indochina where both species are sympatric. The large-scale sharing of MHC class II alleles between the two species in this region supports the hypothesis that genes, and especially genes involved in immune response, are being transferred across the species boundary. This differential introgression has important implications for the incorporation of cynomolgus macaques of unknown geographic origin in biomedical research protocols. Our study found that for 2808 SNP markers, the MAF and observed heterozygosity calculated from a sample of Vietnamese cynomolgus macaques was significantly different from those calculated from samples of both Chinese rhesus and Indonesian cynomolgus macaques. SNP alleles from Chinese rhesus macaques were overrepresented in a sample of Vietnamese cynomolgus macaques relative to their Indonesian conspecifics and located in genes functionally related to the primary immune system. These results suggest that Indochinese cynomolgus macaques represent a genetically and immunologically distinct entity from Indonesian cynomolgus macaques.
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DOI：
10.1111/j.1471-8286.2005.01011.x
发表时间：
2005-09-01
期刊：
MOLECULAR ECOLOGY NOTES
影响因子：
--
作者：
Buerkle, CA
通讯作者：
Buerkle, CA
影响因子：
1.7
作者：
Fooden, J
通讯作者：
Fooden, J
影响因子：
56.9
作者：
FOODEN, J
通讯作者：
FOODEN, J
影响因子：
3.2
作者：
Ling F;Wei LQ;Wang T;Wang HB;Zhuo M;Du HL;Wang JF;Wang XN
通讯作者：
Wang XN
影响因子：
56.9
作者：
Gibbs, Richard A.;Rogers, Jeffrey;Zwieg, Ann S.
通讯作者：
Zwieg, Ann S.