Contrasting patterns of polymorphisms at the ABO-secretor gene (FUT2) and plasma alpha(1,3)fucosyltransferase gene (FUT6) in human populations.
Contrasting patterns of polymorphisms at the ABO-secretor gene (FUT2) and plasma alpha(1,3)fucosyltransferase gene (FUT6) in human populations.
复制标题
人群中 ABO 分泌基因 (FUT2) 和血浆 α(1,3) 岩藻糖基转移酶基因 (FUT6) 多态性的对比模式。
作者：
Y. Koda;H. Tachida;H. Pang;Yuhua Liu;M. Soejima;A. Ghaderi;O. Takenaka;H. Kimura
在5个人群中，通过直接测序分析了FUT 2 [ABO分泌型α（1，2）岩藻糖基转移酶]和FUT 6 [血浆α（1，3）岩藻糖基转移酶]的编码序列（约1 kb）的等位基因多态性。根据成对序列差异估计的FUT 2的核苷酸差异在非洲人、欧洲-非洲人、伊朗人、中国人和日本人中分别为0.0045、0.0042、0.0009和0.0008。FUT 6在非洲人、欧洲-非洲人、伊朗人、中国人和日本人中的核苷酸差异分别为0.0024、0.0016、0.0015、0.0017和0.0020。在FUT 2，过量的成对序列差异相比，多态性位点的数量由一个显着积极的田岛的D在欧洲非洲人和伊朗人。数据不符合期望的平衡中性模型与无限数量的网站。另一方面，五个人群中每一个的FUT 6和非洲人、中国人和日本人的FUT 2的Tajima's D与零没有显著差异。在FUT 2测量的亚洲人和其他人之间的F（ST）高于FUT 6。这些结果表明，自然选择是负责FUT 2多态性在欧洲非洲人和伊朗人的一代。
The coding sequences ( approximately 1 kb) of FUT2 [ABO-Secretor type alpha(1,2)fucosyltransferase] and of FUT6 [plasma alpha(1,3)fucosyltransferase] were analyzed for allelic polymorphism by direct sequencing in five populations. The nucleotide diversities of FUT2 estimated from pairwise sequence differences were 0.0045, 0.0042, 0.0042, 0.0009, and 0.0008 in Africans, European-Africans, Iranians, Chinese, and Japanese, respectively. The nucleotide diversities of FUT6 were 0.0024, 0.0016, 0.0015, 0.0017, and 0.0020 in Africans, European-Africans, Iranians, Chinese, and Japanese, respectively. At FUT2, excesses in pairwise sequence differences compared to the number of polymorphic sites as indicated by a significantly positive Tajima's D were observed in European-Africans and in Iranians. The data do not fit expectations of the equilibrium neutral model with an infinite number of sites. On the other hand, Tajima's D's at FUT6 in each of the five populations and at FUT2 in Africans, Chinese, and Japanese were not significantly different from zero. F(ST) between the Asians and the others measured at FUT2 was higher than at FUT6. These results suggest that natural selection was responsible for the generation of the FUT2 polymorphism in European-Africans and in Iranians.
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