Developmental decoupling of alternative phenotypes: insights from the transcriptomes of horn-polyphenic beetles.
Developmental decoupling of alternative phenotypes: insights from the transcriptomes of horn-polyphenic beetles.
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DOI：
10.1111/j.1558-5646.2010.01106.x
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发表时间：
2011-01
期刊：
影响因子：
--
通讯作者：
Moczek AP
中科院分区：
文献类型：
--
作者：
Snell-Rood EC;Cash A;Han MV;Kijimoto T;Andrews J;Moczek AP
发育机制在决定表型可塑性的代价、限制和进化后果方面起着重要作用。这些主张的一个核心问题是发展脱钩的假设，其中交替变体来自进化上独立的发展途径。我们通过一项微阵列研究来解决这一假设，该研究测试了交替变体之间的基因表达差异是否像性别之间的差异一样不同，这是发展脱钩的一个经典例子。然后，我们研究是否与形态偏置表达的基因是不太保守的基因与形态之间的共享表达，预测如果发展脱钩放松多效性的分歧限制。我们专注于两种角甲虫的角和大脑的发育，角和战斗行为的表达具有壮观的性和形态二型性。我们发现基因表达的模式在不同的变体之间是不同的，就像它们在性别之间一样。然而，基因表达的总体模式也高度相关的跨形态和性别。形态偏向基因更进化分歧，这表明放松多效性约束或放松选择的作用。总之，这些结果表明，交替变形在一定程度上发展脱钩，这种脱钩有显着的进化后果。然而，替代变体可能并不像有时假设的那样在发展上脱钩，这种发展假设应该重新审视和完善。
Developmental mechanisms play an important role in determining the costs, limits, and evolutionary consequences of phenotypic plasticity. One issue central to these claims is the hypothesis of developmental decoupling, where alternate morphs result from evolutionarily independent developmental pathways. We address this assumption through a microarray study that tests whether differences in gene expression between alternate morphs are as divergent as those between sexes, a classic example of developmental decoupling. We then examine whether genes with morph-biased expression are less conserved than genes with shared expression between morphs, as predicted if developmental decoupling relaxes pleiotropic constraints on divergence. We focus on the developing horns and brains of two species of horned beetles with spectacular sexual- and morph-dimorphism in the expression of horns and fighting behavior. We find that patterns of gene expression were as divergent between morphs as they were between sexes. However, overall patterns of gene expression were also highly correlated across morphs and sexes. Morph-biased genes were more evolutionarily divergent, suggesting a role of relaxed pleiotropic constraints or relaxed selection. Together these results suggest that alternate morphs are to some extent developmentally decoupled, and that this decoupling has significant evolutionary consequences. However, alternative morphs may not be as developmentally decoupled as sometimes assumed and such hypotheses of development should be revisited and refined.
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影响因子：
64.8
作者：
Brakefield, PM;Gates, J;Carroll, SB
通讯作者：
Carroll, SB
高度社会性蜜蜂意大利蜜蜂种姓分化的分子决定因素。
影响因子：
--
作者：
Barchuk AR;Cristino AS;Kucharski R;Costa LF;Simões ZL;Maleszka R
通讯作者：
Maleszka R
影响因子：
2.5
作者：
Cash, AC;Whitfield, CW;Robinson, GE
通讯作者：
Robinson, GE
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
56.9
作者：
Brisson, Jennifer A.;Nuzhdin, Sergey V.
通讯作者：
Nuzhdin, Sergey V.