ASGDB: a specialised genomic resource for interpreting Anopheles sinensis insecticide resistance.
ASGDB: a specialised genomic resource for interpreting Anopheles sinensis insecticide resistance.
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ASGDB：用于解释中华按蚊杀虫剂抗性的专门基因组资源。
DOI：
10.1186/s13071-017-2584-8
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发表时间：
2018-01-10
影响因子：
3.2
通讯作者：
Zhu CL
中科院分区：
文献类型：
--
作者：
Zhou D;Xu Y;Zhang C;Hu MX;Huang Y;Sun Y;Ma L;Shen B;Zhu CL
中华按蚊是东南亚重要的疟疾媒介。这种蚊子普遍出现抗药性，对疟疾控制措施的有效性构成严重威胁，特别是在中国。最近，An的全基因组测序和从头组装工作取得了进展。中华绒毛虫(中国品系)已经完成。一系列的杀虫剂抗药性研究。华支睾吸虫也有报道。人们越来越需要整合这些有价值的数据，为进一步研究AN的抗药性管理提供一个全面的数据库。中华绒毛。一个名为An的生物信息学数据库。建立中华鳖基因组数据库(ASGDB)。除了是已出版的和可搜索的数据库之外。为进一步了解基因组和遗传数据，ASGDB提供了深入的分析平台，包括基因组数据可视化、同源关系分析、GO分析、通径分析、表达分析和抗性相关基因分析。此外，ASGDB提供了一个关于杀虫剂抗性研究的全景。中国的中华按蚊。总共有551份关于AN的抗药性表型和基因报告。自20世纪80年代中期以来分布在中国疟疾流行区的中华吸虫被收集起来，以相同的格式进行手动编辑，并集成到基于OpenLayers地图的界面中，这使得国际社会能够更容易地评估和利用大量分散的数据。该数据库的网址为：http://www.asgdb.org/.ASGDB是为了帮助用户从一个人的基因组序列中挖掘数据而建立的。中华按蚊，特别是在抗药性监测和控制方面具有优势。本文的在线版本(10.1186/s13071-0172584-8)包含补充材料，可供授权用户使用。
Anopheles sinensis is an important malaria vector in Southeast Asia. The widespread emergence of insecticide resistance in this mosquito species poses a serious threat to the efficacy of malaria control measures, particularly in China. Recently, the whole-genome sequencing and de novo assembly of An. sinensis (China strain) has been finished. A series of insecticide-resistant studies in An. sinensis have also been reported. There is a growing need to integrate these valuable data to provide a comprehensive database for further studies on insecticide-resistant management of An. sinensis. A bioinformatics database named An. sinensis genome database (ASGDB) was built. In addition to being a searchable database of published An. sinensis genome sequences and annotation, ASGDB provides in-depth analytical platforms for further understanding of the genomic and genetic data, including visualization of genomic data, orthologous relationship analysis, GO analysis, pathway analysis, expression analysis and resistance-related gene analysis. Moreover, ASGDB provides a panoramic view of insecticide resistance studies in An. sinensis in China. In total, 551 insecticide-resistant phenotypic and genotypic reports on An. sinensis distributed in Chinese malaria-endemic areas since the mid-1980s have been collected, manually edited in the same format and integrated into OpenLayers map-based interface, which allows the international community to assess and exploit the high volume of scattered data much easier. The database has been given the URL: http://www.asgdb.org/. ASGDB was built to help users mine data from the genome sequence of An. sinensis easily and effectively, especially with its advantages in insecticide resistance surveillance and control. The online version of this article (10.1186/s13071-017-2584-8) contains supplementary material, which is available to authorized users.
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影响因子：
14.9
作者：
Kanehisa M;Araki M;Goto S;Hattori M;Hirakawa M;Itoh M;Katayama T;Kawashima S;Okuda S;Tokimatsu T;Yamanishi Y
通讯作者：
Yamanishi Y
影响因子：
3.2
作者：
Pan JY;Zhou SS;Zheng X;Huang F;Wang DQ;Shen YZ;Su YP;Zhou GC;Liu F;Jiang JJ
通讯作者：
Jiang JJ
影响因子：
7
作者：
Skinner, Mitchell E.;Uzilov, Andrew V.;Holmes, Ian H.
通讯作者：
Holmes, Ian H.
影响因子：
2
作者：
Fang, Fujin;Wang, Weijie;Zhu, Changliang
通讯作者：
Zhu, Changliang
影响因子：
2.2
作者：
APPERSON, CS;GEORGHIOU, GP
通讯作者：
GEORGHIOU, GP