Pair Bond-Induced Affiliation and Aggression in Male Prairie Voles Elicit Distinct Functional Connectivity in the Social Decision-Making Network.
Pair Bond-Induced Affiliation and Aggression in Male Prairie Voles Elicit Distinct Functional Connectivity in the Social Decision-Making Network.
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DOI：
10.3389/fnins.2021.748431
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发表时间：
2021
影响因子：
4.3
通讯作者：
Smith AS
中科院分区：
文献类型：
--
作者：
Gossman KR;Dykstra B;García BH;Swopes AP;Kimbrough A;Smith AS
复杂的社会行为是由一个神经网络控制的，这个神经网络被理论化为社会决策网络（SDMN）。然而，这一理论网络并没有在功能基础上进行测试。在这里，我们使用c-Fos来评估SDMN区域的组织，以在社会一夫一妻制的啮齿动物草原田鼠（Microtus ochrogaster）的特定社会互动中生成功能连接模型。雄性田鼠对雌性伴侣表现出强烈的选择性隶属关系，同时对新的雄性和雌性表现出更多的威胁、警惕和身体攻击行为。这些社会互动增加了SDMN的13个大脑区域中8个区域的c-Fos水平。每次社交活动都会在大脑的各个区域之间产生一种独特的关联模式。因此，分层聚类被用来表征具有相似c-Fos活动的相关区域，从而产生离散的网络模块。构建功能连接图来模拟每次社会接触所产生的网络动态。我们的合作伙伴功能连接网络呈现出与理论SDMN模型的相似之处，以及网络中涉及合作伙伴导向从属关系的连接。然而，陌生的女性和男性网络都表现出不同于彼此和SDMN的结构。此外，陌生人诱发的网络显示了与威胁、身体攻击和其他厌恶行为相关的联系。综上所述，这表明在特定的社会接触中可以检测到SDMN中不同的功能连接模式。
Complex social behaviors are governed by a neural network theorized to be the social decision-making network (SDMN). However, this theoretical network is not tested on functional grounds. Here, we assess the organization of regions in the SDMN using c-Fos, to generate functional connectivity models during specific social interactions in a socially monogamous rodent, the prairie voles (Microtus ochrogaster). Male voles displayed robust selective affiliation toward a female partner, while exhibiting increased threatening, vigilant, and physically aggressive behaviors toward novel males and females. These social interactions increased c-Fos levels in eight of the thirteen brain regions of the SDMN. Each social encounter generated a distinct correlation pattern between individual brain regions. Thus, hierarchical clustering was used to characterize interrelated regions with similar c-Fos activity resulting in discrete network modules. Functional connectivity maps were constructed to emulate the network dynamics resulting from each social encounter. Our partner functional connectivity network presents similarities to the theoretical SDMN model, along with connections in the network that have been implicated in partner-directed affiliation. However, both stranger female and male networks exhibited distinct architecture from one another and the SDMN. Further, the stranger-evoked networks demonstrated connections associated with threat, physical aggression, and other aversive behaviors. Together, this indicates that distinct patterns of functional connectivity in the SDMN can be detected during select social encounters.
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5.1
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