Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies.
Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies.
复制标题
DOI：
10.1371/journal.pone.0079017
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Leng WD
中科院分区：
文献类型：
--
作者：
Zeng XT;Deng AP;Li C;Xia LY;Niu YM;Leng WD
Many epidemiological studies have found a positive association of periodontal disease (PD) with risk of head and neck cancer (HNC), but the findings are varied or even contradictory. In this work, we performed a meta-analysis to ascertain the relationship between PD and HNC risk. We searched the PubMed, Embase, and Cochrane Library databases for relevant observational studies on the association between PD and HNC risk published up to March 23, 2013. Data from the included studies were extracted and analyzed independently by two authors. Meta-analysis was performed using RevMan 5.2 software. We obtained seven observational studies involving two cohort and six case-control studies. Random-effects meta-analysis indicated a significant association between PD and HNC risk (odds ratio = 2.63, 95% confidence interval = 1.1.68 - 4.14; p < 0.001), with sensitivity analysis showing that the result was robust. Subgroup analyses based on adjustment for covariates, study design, PD assessment, tumor site, and ethnicity also revealed a significant association. Based on currently evidence, PD is probably a significant and independent risk factor of HNC.
登录
查看更多内容
影响因子：
15.8
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
5
作者：
Guha, Neela;Boffetta, Paolo;Brennan, Paul
通讯作者：
Brennan, Paul
影响因子：
1.4
作者：
Rosenquist, K;Wennerberg, J;Andersson, G
通讯作者：
Andersson, G
影响因子：
2.3
作者：
Divaris, Kimon;Olshan, Andrew F.;Smith, Joanna;Bell, Mary E.;Weissler, Mark C.;Funkhouser, William K.;Bradshaw, Patrick T.
通讯作者：
Bradshaw, Patrick T.
影响因子：
51.1
作者：
Michaud, Dominique S.;Liu, Yan;Joshipura, Kaumudi
通讯作者：
Joshipura, Kaumudi