Risk of incident diabetes after COVID-19 infection: A systematic review and meta-analysis.
Risk of incident diabetes after COVID-19 infection: A systematic review and meta-analysis.
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DOI：
10.1016/j.metabol.2022.155330
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发表时间：
2022-12
影响因子：
9.8
通讯作者：
Ge, Long
中科院分区：
文献类型：
--
作者：
Lai, Honghao;Yang, Manli;Sun, Mingyao;Pan, Bei;Wang, Quan;Wang, Jing;Tian, Jinhui;Ding, Guowu;Yang, Kehu;Song, Xuping;Ge, Long
COVID-19 可能是多种慢性疾病的危险因素。然而，COVID-19 与糖尿病风险之间的关联仍不清楚。我们的目的是对有关 COVID-19 患者发生糖尿病相对风险的证据进行荟萃分析。在这项系统回顾和荟萃分析中，检索了 2019 年 12 月至 2022 年 6 月 8 日期间的 Embase、PubMed、CENTRAL 和 Web of Science 数据库。我们纳入了队列研究，这些研究提供了确认 COVID-19 诊断后糖尿病的数量、比例或相对风险的数据。两名评审员独立筛选研究的资格、提取数据并评估偏倚风险。我们使用随机效应荟萃分析来汇总相对风险与相应的 95% 置信区间。进行预先指定的亚组和荟萃回归分析以探讨潜在的影响因素。我们将相对风险转换为绝对风险差异来提供证据。本研究已提前注册（PROSPERO CRD42022337841）。涉及 11 个回顾性队列、总共 4710 万名参与者的 10 篇文章被证明符合资格。我们发现，与非 COVID-19 对照者相比，COVID-19 患者患糖尿病的风险高出 64%（RR = 1.64，95%CI：1.51 至 1.79），这可能会使每 10,000 人中糖尿病事件数量增加 701 例（增加 558 例至 865 例）。我们发现糖尿病类型和性别具有显着的亚组效应。 2 型糖尿病的相对风险高于 1 型糖尿病。此外，男性患糖尿病的总体风险可能高于女性。敏感性分析证实了结果的稳健性。没有发现发表偏倚的证据。 COVID-19 与糖尿病（包括 1 型和 2 型糖尿病）的发病风险密切相关。鉴于感染 COVID-19 的人数众多且不断增加，我们应该意识到 COVID-19 后患糖尿病的风险，并为相关的健康问题做好准备。然而，证据仍需加强。
COVID-19 might be a risk factor for various chronic diseases. However, the association between COVID-19 and the risk of incident diabetes remains unclear. We aimed to meta-analyze evidence on the relative risk of incident diabetes in patients with COVID-19. In this systematic review and meta-analysis, the Embase, PubMed, CENTRAL, and Web of Science databases were searched from December 2019 to June 8, 2022. We included cohort studies that provided data on the number, proportion, or relative risk of diabetes after confirming the COVID-19 diagnosis. Two reviewers independently screened studies for eligibility, extracted data, and assessed risk of bias. We used a random-effects meta-analysis to pool the relative risk with corresponding 95 % confidence intervals. Prespecified subgroup and meta-regression analyses were conducted to explore the potential influencing factors. We converted the relative risk to the absolute risk difference to present the evidence. This study was registered in advance (PROSPERO CRD42022337841). Ten articles involving 11 retrospective cohorts with a total of 47.1 million participants proved eligible. We found a 64 % greater risk (RR = 1.64, 95%CI: 1.51 to 1.79) of diabetes in patients with COVID-19 compared with non-COVID-19 controls, which could increase the number of diabetes events by 701 (558 more to 865 more) per 10,000 persons. We detected significant subgroup effects for type of diabetes and sex. Type 2 diabetes has a higher relative risk than type 1. Moreover, men may be at a higher risk of overall diabetes than women. Sensitivity analysis confirmed the robustness of the results. No evidence was found for publication bias. COVID-19 is strongly associated with the risk of incident diabetes, including both type 1 and type 2 diabetes. We should be aware of the risk of developing diabetes after COVID-19 and prepare for the associated health problems, given the large and growing number of people infected with COVID-19. However, the body of evidence still needs to be strengthened.
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影响因子：
7.7
作者：
Metwally AA;Mehta P;Johnson BS;Nagarjuna A;Snyder MP
通讯作者：
Snyder MP
影响因子：
29
作者：
Coate KC;Cha J;Shrestha S;Wang W;Gonçalves LM;Almaça J;Kapp ME;Fasolino M;Morgan A;Dai C;Saunders DC;Bottino R;Aramandla R;Jenkins R;Stein R;Kaestner KH;Vahedi G;HPAP Consortium;Brissova M;Powers AC
通讯作者：
Powers AC
影响因子：
64.8
作者：
Al-Aly, Ziyad;Xie, Yan;Bowe, Benjamin
通讯作者：
Bowe, Benjamin
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
Covid-19和糖尿病：两种疾病的碰撞和勾结。
影响因子：
7.7
作者：
Feldman EL;Savelieff MG;Hayek SS;Pennathur S;Kretzler M;Pop-Busui R
通讯作者：
Pop-Busui R