Cohort profile: rationale and methods of UK Biobank repeat imaging study eye measures to study dementia.
Cohort profile: rationale and methods of UK Biobank repeat imaging study eye measures to study dementia.
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DOI：
10.1136/bmjopen-2022-069258
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发表时间：
2023-06-23
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
视网膜提供了神经元和血管健康的生物标记物，为认知老化、轻度认知障碍和痴呆症提供了有希望的见解。本文描述了眼睛和视力评估的原理和方法，目的是支持英国生物库重复成像研究中的痴呆症研究。英国生物库是一个大规模、多中心、预期的队列，包含来自2006-2010年英国各地50万名年龄在40-69岁之间的参与者的深入遗传、生活方式、环境和健康信息。队列中的一个子组(最多60000名参与者)将被邀请参加英国生物库重复成像研究，以收集重复的脑、心脏和腹部MRI扫描、全身双能X射线吸收测量、颈动脉超声以及视网膜光学相干断层扫描(OCT)和彩色眼底照片。英国生物库在了解许多常见疾病的风险因素方面取得了重大进展，包括痴呆症和认知能力下降。眼科遗传和流行病学研究也受益于大量参与者的无与伦比的组合、深入的表型分析和队列的纵向跟踪，以及全面的健康数据与疾病结果的联系。此外，我们还使用了英国生物库的数据来描述视网膜结构、认知功能和脑MRI衍生表型之间的关系。作为英国生物库重复成像研究的一部分，与眼睛相关的数据(如OCT)的收集将于2022-2028年进行。这个数据集的深度、广度和纵向性质，加上它的开放获取政策，将为痴呆症诊断发现和更好地了解其与共病疾病的关联创造一个重要的新资源。此外，这项研究中广泛而多样的数据将支持对眼科疾病和痴呆症以外的各种其他健康后果的研究。
The retina provides biomarkers of neuronal and vascular health that offer promising insights into cognitive ageing, mild cognitive impairment and dementia. This article described the rationale and methodology of eye and vision assessments with the aim of supporting the study of dementia in the UK Biobank Repeat Imaging study. UK Biobank is a large-scale, multicentre, prospective cohort containing in-depth genetic, lifestyle, environmental and health information from half a million participants aged 40–69 enrolled in 2006–2010 across the UK. A subset (up to 60 000 participants) of the cohort will be invited to the UK Biobank Repeat Imaging Study to collect repeated brain, cardiac and abdominal MRI scans, whole-body dual-energy X-ray absorptiometry, carotid ultrasound, as well as retinal optical coherence tomography (OCT) and colour fundus photographs. UK Biobank has helped make significant advances in understanding risk factors for many common diseases, including for dementia and cognitive decline. Ophthalmic genetic and epidemiology studies have also benefited from the unparalleled combination of very large numbers of participants, deep phenotyping and longitudinal follow-up of the cohort, with comprehensive health data linkage to disease outcomes. In addition, we have used UK Biobank data to describe the relationship between retinal structures, cognitive function and brain MRI-derived phenotypes. The collection of eye-related data (eg, OCT), as part of the UK Biobank Repeat Imaging study, will take place in 2022–2028. The depth and breadth and longitudinal nature of this dataset, coupled with its open-access policy, will create a major new resource for dementia diagnostic discovery and to better understand its association with comorbid diseases. In addition, the broad and diverse data available in this study will support research into ophthalmic diseases and various other health outcomes beyond dementia.
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影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
48
作者：
Kalaria, Raj N.;Maestre, Gladys E.;Arizaga, Raul;Friedland, Robert P.;Galasko, Doug;Hall, Kathleen;Luchsinger, Jose A.;Ogunniyi, Adesola;Perry, Elaine K.;Potocnik, Felix;Prince, Martin;Stewart, Robert;Wimo, Anders;Zhang, Zhen-Xin;Antuono, Piero
通讯作者：
Antuono, Piero
影响因子：
9.9
作者：
Cruz-Herranz A;Balk LJ;Oberwahrenbrock T;Saidha S;Martinez-Lapiscina EH;Lagreze WA;Schuman JS;Villoslada P;Calabresi P;Balcer L;Petzold A;Green AJ;Paul F;Brandt AU;Albrecht P;IMSVISUAL consortium
通讯作者：
IMSVISUAL consortium
影响因子：
39.3
作者：
Littlejohns TJ;Sudlow C;Allen NE;Collins R
通讯作者：
Collins R
影响因子：
13.7
作者：
Chan MP;Grossi CM;Khawaja AP;Yip JL;Khaw KT;Patel PJ;Khaw PT;Morgan JE;Vernon SA;Foster PJ;UK Biobank Eye and Vision Consortium
通讯作者：
UK Biobank Eye and Vision Consortium