Yokukansan promotes hippocampal neurogenesis associated with the suppression of activated microglia in Gunn rat.
Yokukansan promotes hippocampal neurogenesis associated with the suppression of activated microglia in Gunn rat.
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DOI：
10.1186/1742-2094-10-145
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发表时间：
2013-12-05
影响因子：
9.3
通讯作者：
Horiguchi J
中科院分区：
文献类型：
--
作者：
Furuya M;Miyaoka T;Tsumori T;Liaury K;Hashioka S;Wake R;Tsuchie K;Fukushima M;Ezoe S;Horiguchi J
精神分裂症（SCZ）的病理生理学仍不清楚，其治疗也远不理想。我们以前曾报道，日本传统药物横肝散（YKS）是一种有效的SCZ的治疗药物。然而，YKS的作用机制尚未完全阐明。最近的一项荟萃分析研究表明，辅助抗炎药物对SCZ治疗有效，并且已经提出，与炎症相关的一些认知缺陷可能部分与炎症诱导的成年海马神经发生减少有关。虽然YKS的某些成分具有有效的抗炎活性，但没有研究确定YKS是否具有抗炎特性。使用古恩大鼠，这已被报道为一个可能的动物模型SCZ，我们调查是否YKS影响认知功能障碍的对象定位测试和抑制小胶质细胞的激活和海马神经发生。我们发现，YKS改善古恩大鼠的空间工作记忆。此外，YKS抑制小胶质细胞的激活，促进这些大鼠海马齿状回的神经发生。这些结果表明，YKS对认知缺陷的改善作用可能部分通过抑制小胶质细胞的炎症激活来介导。这些发现揭示了YKS治疗SCZ的可能机制。
The pathophysiology of schizophrenia (SCZ) remains unclear, and its treatment is far from ideal. We have previously reported that yokukansan (YKS), which is a traditional Japanese medicine, is effective as an adjunctive therapy for SCZ. However, the mechanisms underlying the action of YKS have not yet been completely elucidated. A recent meta-analysis study has shown that adjuvant anti-inflammatory drugs are effective for SCZ treatment, and it has been proposed that some of the cognitive deficits associated with inflammation may in part be related to inflammation-induced reductions in adult hippocampal neurogenesis. Although certain ingredients of YKS have potent anti-inflammatory activity, no study has determined if YKS has anti-inflammatory properties. Using the Gunn rat, which has been reported as a possible animal model of SCZ, we investigated whether YKS affects cognitive dysfunction in an object-location test and the suppression of microglial activation and neurogenesis in the hippocampus. We found that YKS ameliorated spatial working memory in the Gunn rats. Furthermore, YKS inhibited microglial activation and promoted neurogenesis in the hippocampal dentate gyrus of these rats. These results suggest that the ameliorative effects of YKS on cognitive deficits may be mediated in part by the suppression of the inflammatory activation of microglia. These findings shed light on the possible mechanism underlying the efficacy of YKS in treating SCZ.
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影响因子：
3.7
作者：
Gazzin S;Berengeno AL;Strazielle N;Fazzari F;Raseni A;Ostrow JD;Wennberg R;Ghersi-Egea JF;Tiribelli C
通讯作者：
Tiribelli C
影响因子：
4.5
作者：
Barrantes-Vidal, Neus;Aguilera, Mari;Fananas, Lourdes
通讯作者：
Fananas, Lourdes
影响因子：
5.7
作者：
Cheng, Chin-Yi;Ho, Tin-Yun;Hsieh, Ching-Liang
通讯作者：
Hsieh, Ching-Liang
DOI：
10.1006/bbrc.1996.1112
发表时间：
1996-07-25
影响因子：
3.1
作者：
Imai, Y;Ibata, I;Kohsaka, S
通讯作者：
Kohsaka, S
影响因子：
6
作者：
Dean, Olivia M.;Data-Franco, Joao;Berk, Michael
通讯作者：
Berk, Michael