Synthesis of an AIEgen functionalized cucurbit[7]uril for subcellular bioimaging and synergistic photodynamic therapy and supramolecular chemotherapy.
Synthesis of an AIEgen functionalized cucurbit[7]uril for subcellular bioimaging and synergistic photodynamic therapy and supramolecular chemotherapy.
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用于亚细胞生物成像和协同光动力治疗和超分子化疗的 AIEgen 功能化葫芦[7]脲的合成
DOI：
10.1039/d1sc01139a
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发表时间：
2021-04-21
期刊：
影响因子：
8.4
通讯作者：
Wang R
中科院分区：
文献类型：
--
作者：
Chen J;Li S;Wang Z;Pan Y;Wei J;Lu S;Zhang QW;Wang LH;Wang R
基于聚集诱导发射（AIE）的荧光团（AIEgens）由于其独特的光学性质而在生物医学应用中引起越来越多的关注。在这里，我们报道了一种AIE光敏剂功能化CB[7]，即AIEB [7]，其可以在水溶液中自发地自组装成纳米聚集体。有趣的是，CB[7]的羰基-花边可能在酸性环境中潜在地充当质子受体，以通过调节AIEgens的内部堆叠来微调AIECB[7]纳米聚集体的荧光和单线态氧产生。此外，受益于CB[7]的客体结合特性，奥沙利铂被纳入AIECB[7]纳米聚集体中，用于联合光动力疗法和超分子化疗。为了显示该超分子系统的模块化多功能性，将低氧可活化的前药班诺蒽醌（AQ 4 N）加载到AECB [7]纳米聚集体中，其在多细胞肿瘤球体模型（MCTS）上表现出协同抗肿瘤作用。这项工作不仅为多功能治疗诊断应用提供了AECB [7]，而且还为设计和开发用于各种生物医学应用的大环缀合AIE材料提供了重要的新见解。首次合成了AIEgen功能化的葫芦[7]脲，并在水溶液中自发自组装成纳米聚集体，并允许溶酶体的亚细胞成像以及癌症的光动力学治疗和化疗。
Aggregation-induced emission (AIE) based fluorophores (AIEgens) have attracted increasing attention for biomedical applications due to their unique optical properties. Here we report an AIE photosensitizer functionalized CB[7], namely AIECB[7], which could spontaneously self-assemble into nanoaggregates in aqueous solutions. Interestingly, the carbonyl-lace of CB[7] may potentially act as a proton acceptor in an acidic environment to fine-tune the fluorescence and singlet oxygen generation of AIECB[7] nanoaggregates by regulating the inner stacking of AIEgens. Additionally, benefiting from the guest-binding properties of CB[7], oxaliplatin was included into AIECB[7] nanoaggregates for combined photodynamic therapy and supramolecular chemotherapy. To show the modular versatility of this supramolecular system, a hypoxia-activatable prodrug banoxantrone (AQ4N) was loaded into AIECB[7] nanoaggregates, which exhibited synergistic antitumor effects on a multicellular tumor spheroid model (MCTS). This work not only provides AIECB[7] for versatile theranostic applications, but also offers important new insights into the design and development of macrocycle-conjugated AIE materials for diverse biomedical applications. An AIEgen-functionalized cucurbit[7]uril was synthesized for the first time and spontaneously self-assembled into nanoaggregates in aqueous solutions and allowed subcellular imaging of the lysosome and photodynamic therapy and chemotherapy of cancer.
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影响因子：
8.4
作者：
Hu C;Grimm L;Prabodh A;Baksi A;Siennicka A;Levkin PA;Kappes MM;Biedermann F
通讯作者：
Biedermann F
影响因子：
16.6
作者：
Qi, Guobin;Hu, Fang;Liu, Bin
通讯作者：
Liu, Bin
影响因子：
9.5
作者：
Chen, Yueyue;Huang, Zehuan;Zhang, Xi
通讯作者：
Zhang, Xi
影响因子：
15
作者：
Bockus, Andrew T.;Smith, Lauren C.;Urbach, Adam R.
通讯作者：
Urbach, Adam R.
影响因子：
9.5
作者：
Li, Meng;Kim, Sungwan;Kim, Kimoon
通讯作者：
Kim, Kimoon