Inappropriate sinus tachycardia in post-COVID-19 syndrome.
Inappropriate sinus tachycardia in post-COVID-19 syndrome.
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DOI：
10.1038/s41598-021-03831-6
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发表时间：
2022-01-07
影响因子：
4.6
通讯作者：
Villuendas R
中科院分区：
文献类型：
--
作者：
Aranyó J;Bazan V;Lladós G;Dominguez MJ;Bisbal F;Massanella M;Sarrias A;Adeliño R;Riverola A;Paredes R;Clotet B;Bayés-Genís A;Mateu L;Villuendas R
不适当的窦性心动过速(IST)是新冠肺炎后综合征(PCS)患者的常见现象，但迄今尚未完全描述。目的：调查PCS患者中IST的患病率和潜在机制。在2020年6月至12月期间连续入院的静息窦性心律频率≥ 为100次/分的患者前瞻性地纳入了这项研究，并进一步进行了立位测试、二维超声心动图、24小时心电监测(心率变异性可替代心脏自主活动)、生活质量和运动能力测试以及血液采样。为评估心脏自主神经功能，对既有SARS-CoV-2感染史的完全康复患者和既往无SARS-CoV-2感染史的患者进行了2：1：1的对比子分析。在200例PCS患者中，40例(20%)符合新冠肺炎综合征的诊断标准(平均年龄40.1岁±10岁，女性85%，轻度新冠肺炎83%)。未发现潜在的结构性心脏病、促炎状态、心肌细胞损伤或缺氧。伴随着大多数心率变异性参数的下降，尤其是与心脏迷走神经张力相关的参数：pNN50(3例3.2 ± 3对10.5 ± 8对未感染的17.3 ± 10；p <； 0.001)和HF频段(246mpn± 179vs.463 ± 295vs.1048 ± 570；p <； 0.001)。肌萎缩侧索硬化症是PCS患者的常见病。心脏自主神经系统失衡伴副交感神经活性降低可能解释了这一现象。
Inappropriate sinus tachycardia (IST) is a common observation in patients with post-COVID-19 syndrome (PCS) but has not yet been fully described to date. To investigate the prevalence and the mechanisms underlying IST in a prospective population of PCS patients. Consecutive patients admitted to the PCS Unit between June and December 2020 with a resting sinus rhythm rate ≥ 100 bpm were prospectively enrolled in this study and further examined by an orthostatic test, 2D echocardiography, 24-h ECG monitoring (heart rate variability was a surrogate for cardiac autonomic activity), quality-of-life and exercise capacity testing, and blood sampling. To assess cardiac autonomic function, a 2:1:1 comparative sub-analysis was conducted against both fully recovered patients with previous SARS-CoV-2 infection and individuals without prior SARS-CoV-2 infection. Among 200 PCS patients, 40 (20%) fulfilled the diagnostic criteria for IST (average age of 40.1 ± 10 years, 85% women, 83% mild COVID-19). No underlying structural heart disease, pro-inflammatory state, myocyte injury, or hypoxia were identified. IST was accompanied by a decrease in most heart rate variability parameters, especially those related to cardiovagal tone: pNN50 (cases 3.2 ± 3 vs. recovered 10.5 ± 8 vs. non-infected 17.3 ± 10; p < 0.001) and HF band (246 ± 179 vs. 463 ± 295 vs. 1048 ± 570, respectively; p < 0.001). IST is prevalent condition among PCS patients. Cardiac autonomic nervous system imbalance with decreased parasympathetic activity may explain this phenomenon.
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影响因子：
5.1
作者：
Karuppan MKM;Devadoss D;Nair M;Chand HS;Lakshmana MK
通讯作者：
Lakshmana MK
影响因子：
9.9
作者：
SCHONDORF, R;LOW, PA
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LOW, PA
影响因子：
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影响因子：
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通讯作者：
Goldstein DS
影响因子：
3.5
作者：
Mittal, CM;Wig, N;Deepak, KK
通讯作者：
Deepak, KK