Electrically Reversible Redox-Switchable Polydopamine Films for Regulating Cell Behavior
Electrically Reversible Redox-Switchable Polydopamine Films for Regulating Cell Behavior
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用于调节细胞行为的电可逆氧化还原可切换聚多巴胺薄膜
DOI:
10.1016/j.electacta.2016.12.189
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发表时间:
2017-02
影响因子:
6.6
通讯作者:
Ning Chengyun
中科院分区:
文献类型:
--
作者:
Tan Guoxin;Liu Yan;Wu Yuxuan;Ouyang Kongyou;Zhou Lei;Yu Peng;Liao Jinwen;Ning Chengyun
Switchable surfaces that respond to external stimuli are important for regulating cell behavior. The results herein suggest that the redox process of polydopamine (PDA) is a switching reaction between oxidized polydopamine and reduced polydopamine, involving an interconversion of coupled two-proton (2H+) and two-electron (2e−) processes. The redox-switchable reversible surface potential arising from the potential-tunable redox reaction of the phenolic and quinone groups on PDA on titanium induced both cell adhesion and spreading. In vitro experiments demonstrated that the quinone groups on PDA greatly enhanced pre-osteoblasts MC3T3-E1 cell spreading and proliferation. Phenolic groups enhanced the induction of differentiation. The proposed methodology may allow further investigation of switchable surfaces for biological and medical applications.
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