Mapping the natural variation in whole bone stiffness and strength across skeletal sites.
Mapping the natural variation in whole bone stiffness and strength across skeletal sites.
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绘制骨骼部位整体骨骼刚度和强度的自然变化图。
DOI：
10.1016/j.bone.2014.06.031
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发表时间：
2014
期刊：
影响因子：
4.1
通讯作者：
Jepsen,KarlJ
中科院分区：
文献类型：
--
作者：
Schlecht,StephenH;Bigelow,ErinMR;Jepsen,KarlJ
骨骼系统的特征被协调地调整以建立响应于遗传和环境因素的机械稳态。先前的工作表明，这种“复杂的自适应”过程并不完美，揭示了整个人群胫骨的整个骨硬度的两倍差异。耐用性（具体而言，总横截面积相对于长度）在骨骼部位和性别之间差异很大。然而，目前尚不清楚整个骨骼刚度和强度的自然变化是否也在骨骼部位之间以及男性和女性之间变化。我们检验了以下假设：1）无脊椎骨骼的所有主要长骨都表现出内在的、系统性的限制，在一定程度上可以调整形态和组成特征以获得给定的健壮性; 2）这些特征以可预测的方式协变，与身体大小和健壮性无关。我们评估了115名成年男性和女性上肢和下肢长骨的稳健性、皮质面积（Ct.Ar）、皮质组织矿物质密度（Ct.TMD）和骨强度指数（BSI）之间的功能关系。在调整身体尺寸后，所有骨骼都显示出BSI和健壮性之间的显著（p < 0.001）正回归，与健壮骨骼相比，男性细长骨骼的僵硬和强壮程度低1.7-2.3倍，女性的僵硬和强壮程度低1.3-2.8倍。我们的研究结果是第一个记录自然个体间的变化，在整个骨刚度和强度，存在于人群中，这是可预测的基础上骨骼健壮的所有主要长骨。记录和进一步了解这种强度的自然变化可能对鉴别诊断和治疗骨骼脆弱性至关重要。
Traits of the skeletal system are coordinately adjusted to establish mechanical homeostasis in response to genetic and environmental factors. Prior work demonstrated that this ‘complex adaptive’ process is not perfect, revealing a two-fold difference in whole bone stiffness of the tibia across a population. Robustness (specifically, total cross-sectional area relative to length) varies widely across skeletal sites and between sexes. However, it is unknown whether the natural variation in whole bone stiffness and strength also varies across skeletal sites and between men and women. We tested the hypotheses that: 1) all major long bones of the appendicular skeleton demonstrate inherent, systemic constraints in the degree to which morphological and compositional traits can be adjusted for a given robustness; and 2) these traits covary in a predictable manner independent of body size and robustness. We assessed the functional relationships among robustness, cortical area (Ct.Ar), cortical tissue mineral density (Ct.TMD), and bone strength index (BSI) across the long bones of the upper and lower limbs of 115 adult men and women. All bones showed a significant (p < 0.001) positive regression between BSI and robustness after adjusting for body size, with slender bones being 1.7–2.3 times less stiff and strong in men and 1.3–2.8 times less stiff and strong in women compared to robust bones. Our findings are the first to document the natural inter-individual variation in whole bone stiffness and strength that exist within populations and that is predictable based on skeletal robustness for all major long bones. Documenting and further understanding this natural variation in strength may be critical for differentially diagnosing and treating skeletal fragility.
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DOI：
10.1249/mss.0b013e3181893cb7
发表时间：
2008-11-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Evans, Rachel K.;Negus, Charles;Moran, Daniel S.
通讯作者：
Moran, Daniel S.
我们是否充分利用了骨质疏松症的药理治疗选择越来越多？
影响因子：
4
作者：
Jepsen, Karl J.;Schlecht, Stephen H.;Kozloff, Kenneth M.
通讯作者：
Kozloff, Kenneth M.
影响因子：
6.2
作者：
Nieves, JW;Formica, C;Cosman, F
通讯作者：
Cosman, F
DOI：
10.1073/pnas.1010674108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Marder, Eve
通讯作者：
Marder, Eve
影响因子：
6.2
作者：
Epelboym, Yan;Gendron, R. Nicholas;Jepsen, Karl J.
通讯作者：
Jepsen, Karl J.