Learning to collaborate: bringing together behavior and quantitative genomics

Learning to collaborate: bringing together behavior and quantitative genomics
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学习协作:将行为和定量基因组学结合起来

DOI:
10.1080/01677063.2019.1710145
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发表时间:
2020
影响因子:
1.9
通讯作者:
King, Elizabeth G.
King, Elizabeth G.
中科院分区:
医学4区
文献类型:
--
作者:
Williams-Simon, Patricka A.;Ganesan, Mathangi;King, Elizabeth G.

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几十年来,学习和记忆等复杂特征的遗传基础已经得到了很好的研究。通过这些开创性的发现,我们现在对一些与学习和/或记忆有关的基因和途径有了更好的了解。然而,这些发现中很少有识别出影响人群学习和/或记忆的自然分离变量。在这期纪念特洛伊·扎尔斯遗产的特刊中,我们回顾了一些传统的方法,这些方法已经被用来阐明学习和/或记忆的遗传基础,特别是在果蝇中。我们重点介绍了他在该领域的一些贡献,并具体描述了他将行为和数量基因组学结合在一起的愿景,目的是扩大我们对学习和记忆的遗传基础的知识。最后,我们介绍了我们在这一领域的一些最新工作,使用多亲群体(MPP)作为案例研究,并描述了这种方法的潜力,以促进我们对神经遗传学的理解。
The genetic basis of complex trait like learning and memory have been well studied over the decades. Through those groundbreaking findings, we now have a better understanding about some of the genes and pathways that are involved in learning and/or memory. However, few of these findings identified the naturally segregating variants that are influencing learning and/or memory within populations. In this special issue honoring the legacy of Troy Zars, we review some of the traditional approaches that have been used to elucidate the genetic basis of learning and/or memory, specifically in fruit flies. We highlight some of his contributions to the field, and specifically describe his vision to bring together behavior and quantitative genomics with the aim of expanding our knowledge of the genetic basis of both learning and memory. Finally, we present some of our recent work in this area using a multiparental population (MPP) as a case study and describe the potential of this approach to advance our understanding of neurogenetics.
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发表时间: 2012-08-17
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