A compact system for intraoperative specimen imaging based on edge illumination x-ray phase contrast.
A compact system for intraoperative specimen imaging based on edge illumination x-ray phase contrast.
复制标题
基于边缘照明X射线相对比的术中标本成像的紧凑系统。
DOI：
10.1088/1361-6560/ab4912
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发表时间：
2019-11-26
影响因子：
3.5
通讯作者：
Olivo A
中科院分区：
文献类型：
--
作者：
Havariyoun G;Vittoria FA;Hagen CK;Basta D;Kallon GK;Endrizzi M;Massimi L;Munro P;Hawker S;Smit B;Astolfo A;Larkin OJ;Waltham RM;Shah Z;Duffy SW;Nelan RL;Peel A;Suaris T;Jones JL;Haig IG;Bate D;Olivo A
大量因浸润性癌和导管原位癌（DCIS）接受保乳手术（BCS）的患者可能需要在最终组织病理学检查肿瘤阳性边缘后再次手术。目前所有的术中切缘评估方式都有特定的局限性。作为第一步，对一个紧凑的系统，术中标本成像的基础上，边缘照明X射线相衬的发展，我们证明了系统的尺寸可以减少，而不影响成像性能。我们分析了噪声和对比度噪声比（CNR）的变化与减少系统长度使用边缘照明X射线相衬成像设置。对定制体模和乳腺组织标本进行二维（平面）和三维（计算机断层扫描（CT））成像采集。使用专用的相位恢复算法来分离折射和吸收信号。由于其简单的采集程序和减少的采集时间，还使用了“单次”检索方法来检索厚度图图像。实验结果进行了比较，在适当的数值模拟。积分探测器中暗噪声信号的相对贡献对于低光子计数统计采集是重要的。在恒定的曝光系数和放大率下，更紧凑的系统提供了CNR的增加。与吸收图像相比，屈光和厚度图图像获得了上级CNR结果。结果表明，“单次拍摄”采集方法是最好的紧凑型CT术中标本扫描仪，它允许更短的采集时间，其吸收和折射信号的组合，最终导致更高的对比度。与较长长度的系统相比，使用紧凑型系统采集的乳房标本的第一个CT图像提供了有希望的结果。
A significant number of patients receiving breast-conserving surgery (BCS) for invasive carcinoma and ductal carcinoma in situ (DCIS) may need reoperation following tumor-positive margins from final histopathology tests. All current intraoperative margin assessment modalities have specific limitations. As a first step towards the development of a compact system for intraoperative specimen imaging based on edge illumination x-ray phase contrast, we prove that the system’s dimensions can be reduced without affecting imaging performance. We analysed the variation in noise and contrast to noise ratio (CNR) with decreasing system length using the edge illumination x-ray phase contrast imaging setup. Two-(planar) and three-(computed tomography (CT)) dimensional imaging acquisitions of custom phantoms and a breast tissue specimen were made. Dedicated phase retrieval algorithms were used to separate refraction and absorption signals. A ‘single-shot’ retrieval method was also used, to retrieve thickness map images, due to its simple acquisition procedure and reduced acquisition times. Experimental results were compared to numerical simulations where appropriate. The relative contribution of dark noise signal in integrating detectors is significant for low photon count statistics acquisitions. Under constant exposure factors and magnification, a more compact system provides an increase in CNR. Superior CNR results were obtained for refraction and thickness map images when compared to absorption images. Results indicate that the ‘single-shot’ acquisition method is preferable for a compact CT intraoperative specimen scanner; it allows for shorter acquisition times and its combination of the absorption and refraction signals ultimately leads to a higher contrast. The first CT images of a breast specimen acquired with the compact system provided promising results when compared to those of the longer length system.
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影响因子：
3
作者：
Singletary, SE
通讯作者：
Singletary, SE
影响因子：
3
作者：
Karni, Tami;Pappo, Itzhak;Lelcuk, Shlomo
通讯作者：
Lelcuk, Shlomo
影响因子：
1.9
作者：
Olivo, Alessandro;Ignatyev, Konstantin;Speller, Robert D.
通讯作者：
Speller, Robert D.
影响因子：
3.8
作者：
Modregger, P.;Pinzer, B. R.;Stampanoni, M.
通讯作者：
Stampanoni, M.
影响因子：
4.6
作者：
Diemoz, P. C.;Hagen, C. K.;Olivo, A.
通讯作者：
Olivo, A.