The hot 'n' cold of cue-induced drug relapse.
The hot 'n' cold of cue-induced drug relapse.
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DOI：
10.1101/lm.046995.117
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Robinson TE
中科院分区：
文献类型：
--
作者：
Pitchers KK;Sarter M;Robinson TE
与奖励相关的环境线索可以获得动机属性。然而，奖励线索在多大程度上获得对行为的动机控制，这取决于个体和线索的形式，存在相当大的差异。当一个离散的线索与食物奖励配对时，一些大鼠（信号追踪者，st）比其他大鼠（目标追踪者，gt）对动机行为的控制更强，这表明它们倾向于接近线索，愿意努力获得线索，并有能力恢复寻求奖励的行为。在此，我们回顾了采用这种ST/GT动物模型的研究，以研究特别容易受到奖励线索诱导的行为的个体的特征，以及多巴胺和乙酰胆碱神经调节系统在线索诱导的药物复发易感性中的作用。首先，我们讨论了不同形式的奖励线索和中脑边缘多巴胺系统对激励显著性归因的个体差异。然后，我们讨论了认知/注意力控制的个体差异以及胆碱能系统在处理奖励线索中的作用。这表明，在STs中，将动机属性归因于药物线索的倾向与面对这些线索时较差的注意力控制相结合，使他们特别容易从偶然/实验性药物使用模式过渡到成瘾和线索诱导的复发。
Environmental cues associated with rewards can acquire motivational properties. However, there is considerable variation in the extent to which a reward cue gains motivational control over behavior, depending on the individual and the form of the cue. When a discrete cue is paired with food reward, it acquires greater control over motivated behavior in some rats (sign-trackers, STs) than others (goal-trackers, GTs) as indicated by the propensity to approach the cue, the willingness to work to obtain it, and its ability to reinstate reward-seeking behavior. Here, we review studies that employ this ST/GT animal model to investigate characteristics of individuals that are especially susceptible to reward cue-elicited behavior and the involvement of dopamine and acetylcholine neuromodulator systems in the susceptibility to cue-induced drug relapse. First, we discuss individual differences in the attribution of incentive salience to different forms of reward cues and the involvement of the mesolimbic dopamine system. We then discuss individual differences in cognitive/attentional control and the contributions of the cholinergic system in processing reward cues. It is suggested that in STs a propensity to attribute motivational properties to a drug cue is combined with poor attentional control in the face of these cues, making them particularly vulnerable to transition from casual/experimental patterns of drug use to addiction and to cue-induced relapse.
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影响因子：
64.8
作者：
Flagel SB;Clark JJ;Robinson TE;Mayo L;Czuj A;Willuhn I;Akers CA;Clinton SM;Phillips PE;Akil H
通讯作者：
Akil H
影响因子：
3.4
作者：
Capriles, N;Rodaros, D;Stewart, J
通讯作者：
Stewart, J
影响因子：
5.3
作者：
Carr, DB;O'Donnell, P;Sesack, SR
通讯作者：
Sesack, SR
影响因子：
3.4
作者：
EHRMAN, RN;ROBBINS, SJ;OBRIEN, CP
通讯作者：
OBRIEN, CP
影响因子：
5.3
作者：
Di Ciano, P;Cardinal, RN;Everitt, BJ
通讯作者：
Everitt, BJ