Aggressive Posterior Retinopathy of Prematurity Is Associated with Multiple Infectious Episodes and Thrombocytopenia.
Aggressive Posterior Retinopathy of Prematurity Is Associated with Multiple Infectious Episodes and Thrombocytopenia.
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DOI：
10.1159/000448161
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发表时间：
2017
期刊：
影响因子：
2.5
通讯作者：
Hellström A
中科院分区：
文献类型：
--
作者：
Lundgren P;Lundberg L;Hellgren G;Holmström G;Hård AL;Smith LE;Wallin A;Hallberg B;Hellström A
快速进展的早产儿视网膜病变（ROP）的最严重形式被称为侵袭性后视网膜病变（APROP）。尽管进行了及时和适当的激光治疗，但APROP经常导致受影响的早产儿严重视力损害。我们在瑞典的一个国家队列中调查了与APROP发展相关的出生后特征。这项回顾性、1：1匹配的病例对照研究包括2008-2012年在1区（n=9）发生APROP的所有婴儿。胎龄和出生体重相匹配的对照组婴儿的ROP不低于2期（n=9）。我们从婴儿出生特征、出生后发病率和从出生到第一次ROP治疗的血液分析的医疗记录中检索数据。感染发作包括败血症、C反应蛋白≥10 mg/L和其他需要抗生素治疗的感染临床体征。血小板计数<100×109/L视为血小板减少症。所有APROP病例在出生后至少发生两次感染，一次在第一个月，一次在ROP诊断前后。所有APROP病例在第一个月表现出血小板减少症，6/9例在ROP诊断时表现出血小板减少症。与对照组相比，APROP病例更常发生坏死性小肠结肠炎（8/9 vs. 1/9; p<0.01）和脓毒症（9/9 vs. 3/9; p<0.01），并且血小板计数中位数显著较低（90 × 109/L，范围：4-459 vs. 158 × 109/L，范围：20-500; p<0.001）。多发性感染发作和血小板减少症，特别是在ROP诊断前后，与APROP的发生相关。
The most severe form of rapidly progressing retinopathy of prematurity (ROP) is termed aggressive posterior ROP (APROP). APROP frequently causes severe visual impairment in affected preterm infants despite timely and appropriate laser treatment. We investigated postnatal characteristics associated with APROP development in a national Swedish cohort. This retrospective, 1:1 matched, case-control study included all infants that developed APROP in zone 1 (n=9) in 2008-2012. Control infants, matched for gestational age and birth weight, developed ROP no worse than stage 2 (n=9). We retrieved data from medical records on infant birth characteristics, postnatal morbidities, and blood analyses from birth to the first ROP treatment. Infectious episodes included sepsis, C-reactive protein ≥10 mg/L, and other clinical signs of infection that required antibiotic treatment. A platelet count <100×109/L was considered thrombocytopenia. All APROP cases postnatally developed at least two infectious episodes, one in the first month and one around the ROP diagnosis. All APROP cases exhibited thrombocytopenia in the first month, and 6/9 exhibited thrombocytopenia around time for ROP diagnosis. Compared to controls, APROP cases more frequently developed necrotizing enterocolitis (8/9 vs. 1/9; p<0.01) and sepsis (9/9 vs. 3/9; p<0.01), and they had significantly lower median platelet counts (90 × 109/L, range: 4-459 vs. 158 × 109/L, range: 20-500; p<0.001). Multiple infectious episodes and thrombocytopenia, particularly around the time for ROP diagnosis, were associated with APROP development.
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影响因子：
8
作者：
Christensen, Robert D.;Yoder, Bradley A.;Butler, Allison
通讯作者：
Butler, Allison
影响因子：
8
作者：
Klinger, Gil;Levy, Itzhak;Reichman, Brian
通讯作者：
Reichman, Brian
DOI：
10.1097/iae.0b013e3181cafc30
发表时间：
2010-04-01
期刊：
Retina (Philadelphia, Pa.)
影响因子：
--
作者：
Vinekar, Anand;Hegde, Kaushik;Shetty, K Bhujang
通讯作者：
Shetty, K Bhujang
影响因子：
1.2
作者：
Rastogi, Shantanu;Olmez, Inan;Rastogi, Deepa
通讯作者：
Rastogi, Deepa
影响因子：
3.6
作者：
Borroni C;Carlevaro C;Morzenti S;De Ponti E;Bozzetti V;Console V;Capobianco S;Tagliabue PE;Italian ROP study group
通讯作者：
Italian ROP study group