Cross-regional phase amplitude coupling supports the encoding of episodic memories.
Cross-regional phase amplitude coupling supports the encoding of episodic memories.
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DOI：
10.1002/hipo.23309
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发表时间：
2021-05
期刊：
影响因子：
3.5
通讯作者：
Lega BC
中科院分区：
文献类型：
--
作者：
Wang DX;Schmitt K;Seger S;Davila CE;Lega BC
θ和γ振荡之间的相位振幅耦合（PAC）代表了促进振荡活动时间组织的关键神经生理机制。出于这个原因，PAC已牵连在项目/上下文整合的情节过程，包括协调活动跨多个皮层区域。虽然人类的数据主要集中在单个大脑区域内的PAC，但啮齿动物的数据揭示了海马theta振荡的相位调节皮质中的伽马振荡（反之亦然）的证据。这种模式被称为跨区域PAC（xPAC），以前没有在参与记忆处理的人类受试者中观察到。我们使用一个独特的数据集，颅内电极同时插入40名人类受试者的海马和7个皮质区域，以（1）测试显著跨区域PAC（xPAC）的存在，（2）确定xPAC的大小预测记忆编码的成功，（3）描述在2-9 Hz θ范围内的特定频率，这些频率控制xPAC中的海马-皮质相互作用，以及（4）比较前海马xPAC模式与后海马xPAC模式。我们发现，强大的功能xPAC主要发生在海马和其他内侧颞叶结构，即内嗅和海马旁皮质之间，xPAC是整体较强的后海马连接。我们还表明，我们的研究结果不混淆的替代因素，如区域间的相位同步，局部PAC发生在皮层区域内，或人为的θ振荡波形。
Phase amplitude coupling (PAC) between theta and gamma oscillations represents a key neurophysiological mechanism that promotes the temporal organization of oscillatory activity. For this reason, PAC has been implicated in item/context integration for episodic processes, including coordinating activity across multiple cortical regions. While data in humans has focused principally on PAC within a single brain region, data in rodents has revealed evidence that the phase of the hippocampal theta oscillation modulates gamma oscillations in the cortex (and vice versa). This pattern, termed cross-regional PAC (xPAC), has not previously been observed in human subjects engaged in mnemonic processing. We use a unique dataset with intracranial electrodes inserted simultaneously into the hippocampus and seven cortical regions across 40 human subjects to (1) test for the presence of significant cross-regional PAC (xPAC), (2) to establish that the magnitude of xPAC predicts memory encoding success, (3) to describe specific frequencies within the broad 2–9 Hz theta range that govern hippocampal-cortical interactions in xPAC, and (4) compare anterior versus posterior hippocampal xPAC patterns. We find that strong functional xPAC occurs principally between the hippocampus and other mesial temporal structures, namely entorhinal and parahippocampal cortices, and that xPAC is overall stronger for posterior hippocampal connections. We also show that our results are not confounded by alternative factors such as inter-regional phase synchrony, local PAC occurring within cortical regions, or artifactual theta oscillatory waveforms.
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