Genetic variation in resistance and high fecundity impede viral biocontrol of invasive fish
Genetic variation in resistance and high fecundity impede viral biocontrol of invasive fish
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抗性和高繁殖力的遗传变异阻碍了入侵鱼类的病毒生物防治
DOI：
10.1111/1365-2664.13762
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发表时间：
2020
影响因子：
5.7
通讯作者：
Mintram K
中科院分区：
文献类型：
--
作者：
Mintram K
鲤鱼（Cyprinus carpius）是全球最具侵略性的脊椎动物之一，可造成严重的生态破坏。澳大利亚政府的国家鲤鱼控制计划（NCCP）建议释放锦鲤疱疹病毒（KHV），以根除野生鲤鱼，这是有史以来最大的生态干预措施之一。针对水生物种释放高致病性病毒生物控制剂的生态和人类健康风险已得到强调。KHV的有效性也受到质疑，它还没有被证明会产生持久的种群减少。我们开发了一个基于个体的模型（IBM）来研究KHV释放后鲤鱼种群的生态和进化反应。这模拟了鱼类生活史、病毒流行病学、宿主遗传抗性和种群人口统计学之间的相互作用，以严格评估在最佳条件和疾病传播的“最佳情况”下KHV释放的影响。KHV很少会导致长期减少或种群灭绝。至关重要的是，现实的情况导致耐药个体的数量迅速反弹。旨在降低鲤鱼种群恢复率的其他措施（例如，基因工程）需要快速的效力，以显着减少鲤鱼数量以及KHV。鱼类繁殖力具有压倒性的影响，作为一种生物控制剂，当结合遗传抗性的人口。当鲤鱼繁殖力降低到生物学观测值的1%时，种群灭绝的可能性很高。综合与应用。我们使用一个基于个体的模型来评估锦鲤疱疹病毒生物防治在鲤鱼中的效果，发现高宿主繁殖力与遗传抗性相结合，导致初始大型鱼类死亡后的快速种群反弹。随着抗性基因频率的增加，依赖自然选择的生物防治方法在连续几代中失去效力。考虑到病毒释放后大量鱼类死亡带来的密集后勤工作以及对生态系统和人类健康的风险，我们建议持续的人工清除，以及有利于本地物种恢复的生态恢复，为减少种群提供了一种无风险的方法。
Common carpCyprinus carpiois one of the top global invasive vertebrates and can cause significant ecological damage. The Australian Government's National Carp Control Program (NCCP) proposes to release Koi herpesvirus (KHV) to eradicate feral carp in one of the largest ecological interventions ever attempted. Ecological and human health risks have been highlighted regarding the release of a highly pathogenic viral biocontrol for an aquatic species. The efficacy of KHV has also been questioned, and it has not been demonstrated to produce lasting population reductions.We developed an individual‐based model (IBM) to examine the ecological and evolutionary response of a carp population after KHV release. This simulated the interaction between fish life history, viral epidemiology, host genetic resistance and population demography to critically evaluate the impact of KHV release under optimal conditions and a ‘best‐case scenario’ for disease transmission.KHV will rarely result in prolonged reductions or population extinctions. Crucially, realistic scenarios result in a rapidly rebounding population of resistant individuals. Additional measures aimed to reduce carp population recovery rate (e.g. with genetic engineering) require rapid efficacy to significantly reduce carp numbers alongside KHV.Fish fecundity has an overwhelming influence on viral efficacy as a biocontrol agent when combined with genetic resistance within a population. A high probability of population extinction is only met when carp fecundity is reduced to 1% of biological observations.Synthesis and applications. We use an individual‐based model to evaluate the efficacy of Koi herpesvirus biocontrol in Common Carp, and find that high host fecundity combined with genetic resistance results in rapid population rebound after initial large fish kills. Biocontrol approaches relying on natural selection lose efficacy over successive generations as resistance genes increase in frequency. Given the intense logistical effort and risks to ecosystems and human health associated with large fish kills after viral release, we suggest that sustained manual removal, alongside ecological restoration to favour recovery of native species, provides a risk‐free approach to reducing populations.
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影响因子：
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DOI：
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2012
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影响因子：
1.4
作者：
K. Sivakumaran;P. Brown;D. Stoessel;A. Giles
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DOI：
10.1002/rrr.3450110310
发表时间：
1995-11-01
期刊：
REGULATED RIVERS-RESEARCH & MANAGEMENT
影响因子：
--
作者：
Gehrke, PC;Brown, P;Bruce, AM
通讯作者：
Bruce, AM