From loci to networks and back again: anomalies in the study of autism.
From loci to networks and back again: anomalies in the study of autism.
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DOI：
10.1196/annals.1416.014
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发表时间：
2008-12
影响因子：
5.2
通讯作者：
Müller RA
中科院分区：
文献类型：
--
作者：
Müller RA
Recent developments in functional imaging as well as the emergence of new anatomical imaging techniques suited for the study of white matter have shifted investigational paradigms from a localized to a more holistic, network approach. Aside from providing physiological information, functional MRI can be applied to the study of connectivity. However, the concept of “functional connectivity” remains broad, and specific designs and analyses may affect the results. In addition, connectivity cannot be viewed in isolation. Rather, from a developmental perspective, connectivity and local cortical architecture are intimately related. Therefore, combined approaches examining local organization and connectivity are the most promising avenues for elucidating disturbances of neurofunctional organization in developmental disorders. Here this paradigm shift is illustrated via data obtained from autism research, wherein partially converging evidence suggests reduced long-range connectivity between cerebral regions,.
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