Integrated circuits and molecular components for stress and feeding: implications for eating disorders.
Integrated circuits and molecular components for stress and feeding: implications for eating disorders.
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DOI：
10.1111/gbb.12185
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Kash TL
中科院分区：
文献类型：
--
作者：
Hardaway JA;Crowley NA;Bulik CM;Kash TL
饮食失调是一种复杂的脑部疾病，困扰着全世界数百万人。这些疾病的病因尚不完全清楚，但越来越多的文献表明，压力和焦虑可能在其发展中发挥关键作用。随着我们对导致神经性厌食症、神经性贪食症和暴食症等临床人群疾病的遗传和环境因素的了解不断加深，神经科学家正在使用动物模型来了解压力和进食的神经生物学。我们假设饮食失调的临床表型可能是由应激引起的调节进食的神经回路的适应不良改变引起的，并且可以使用饮食失调的动物模型对这些回路进行神经化学分离。
Eating disorders are complex brain disorders that afflict millions of individuals worldwide. The etiology of these diseases is not fully understood, but a growing body of literature suggests that stress and anxiety may play a critical role in their development. As our understanding of the genetic and environmental factors that contribute to disease in clinical populations like anorexia nervosa, bulimia nervosa and binge eating disorder continue to grow, neuroscientists are using animal models to understand the neurobiology of stress and feeding. We hypothesize that eating disorder clinical phenotypes may result from stress-induced maladaptive alterations in neural circuits that regulate feeding, and that these circuits can be neurochemically isolated using animal model of eating disorders.
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