Maze model to study spatial learning and memory in freely moving monkeys
Maze model to study spatial learning and memory in freely moving monkeys
复制标题
研究自由移动猴子空间学习和记忆的迷宫模型
DOI：
10.1016/j.jneumeth.2007.12.017
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发表时间：
2008-05
影响因子：
3
通讯作者：
Carlson S
中科院分区：
文献类型：
--
作者：
Meng ZQ;Hu XT;Wilson AWF;Wang JH;Sun NL;Li CY;Tan H;Ma YY;Zhang B;Carlson S
许多类型的迷宫已被用于认知脑研究，从这些实验中获得的数据，特别是从啮齿动物的研究中获得的数据，支持海马体与空间学习和记忆有关的观点。但非人灵长类动物海马在空间学习和记忆中的作用的研究结果是有争议的，并与啮齿类动物的结果不一致。这可能是由于非人灵长类动物和啮齿类动物使用的方法不同。目前已经建立了几种非人灵长类动物的迷宫模型，包括二维计算机视觉迷宫模型和三维迷宫模型，但它们都存在一定的缺陷。因此，开发一个非人灵长类动物的迷宫模型，与啮齿类动物中使用的迷宫模型是必要的，以解决争议。本文描述了一个大规模的，三维的非人灵长类动物的户外迷宫模型，可用于研究空间学习和记忆。与二维计算机视觉迷宫相比，猴子学习使用迷宫更快。它具有许多优点，可以弥补现有的非人灵长类动物的三维迷宫的局限性，并可以与啮齿类动物的径向臂迷宫相媲美。基于这些结果，我们相信这种新的迷宫模型在许多研究领域，特别是在涉及自由移动猴子的空间学习和记忆的研究中将是有价值的。
Many types of mazes have been used in cognitive brain research and data obtained from those experiments, especially those from rodents’ studies, support the idea that the hippocampus is related to spatial learning and memory. But the results from non-human primates researches regarding the role of the hippocampus in spatial learning and memory are controversial and inconsistent with those obtained in rodents. This might be due to the differences of the methods used in non-human primates and rodents. Several kinds of maze models including two-dimensional computerized visual maze models and three-dimensional maze models have been developed for non-human primates, but they all have some defects. Therefore, development of a maze model for non-human primates that is comparable with those used in rodents is necessary to solve the controversy. This paper describes a large-scale, three-dimensional outdoor maze model for non-human primates which can be used to study spatial learning and memory. Monkeys learn to use the maze quickly compared with two-dimensional computerized visual mazes. It has many advantages which could make up the limits of the existing three-dimensional mazes in non-human primates, and can be comparable with radial arm mazes used in rodents. Based on the results, we believe that the new maze model will be valuable in many research areas, especially in studies involving spatial learning and memory in freely moving monkeys.
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影响因子：
3
作者：
M. A. D. S. Silva;E. L. Mello;C. Müller;G. Jocham;R. Maior;J. Huston;C. Tomaz;M. Barros
通讯作者：
M. A. D. S. Silva;E. L. Mello;C. Müller;G. Jocham;R. Maior;J. Huston;C. Tomaz;M. Barros
影响因子：
25
作者：
G. Winocur;G. Winocur;Morris Moscovitch;M. Moscovitch;S. Fogel;R. Rosenbaum;M. Sekeres
通讯作者：
G. Winocur;G. Winocur;Morris Moscovitch;M. Moscovitch;S. Fogel;R. Rosenbaum;M. Sekeres
影响因子：
3.5
作者：
Hori, E;Nishio, Y;Nishijo, H
通讯作者：
Nishijo, H
影响因子：
3.7
作者：
Crowe, DA;Chafee, MV;Georgopoulos, AP
通讯作者：
Georgopoulos, AP
影响因子：
2
作者：
Elisabeth A. Murray;M. Davidson;D. Gaffan;D. Olton;S. Suomi
通讯作者：
Elisabeth A. Murray;M. Davidson;D. Gaffan;D. Olton;S. Suomi