Immunity to SARS-CoV-2 up to 15 months after infection.
Immunity to SARS-CoV-2 up to 15 months after infection.
复制标题
感染后15个月内对SARS-COV-2的免疫力。
DOI：
10.1016/j.isci.2022.103743
复制
发表时间：
2022-02-18
期刊：
影响因子：
5.8
通讯作者：
Pan-Hammarström Q
中科院分区：
文献类型：
--
作者：
Marcotte H;Piralla A;Zuo F;Du L;Cassaniti I;Wan H;Kumagai-Braesh M;Andréll J;Percivalle E;Sammartino JC;Wang Y;Vlachiotis S;Attevall J;Bergami F;Ferrari A;Colaneri M;Vecchia M;Sambo M;Zuccaro V;Asperges E;Bruno R;Oggionni T;Meloni F;Abolhassani H;Bertoglio F;Schubert M;Calzolai L;Varani L;Hust M;Xue Y;Hammarström L;Baldanti F;Pan-Hammarström Q
关于SARS-CoV-2自然感染后免疫力的持久性的信息可能对疫苗诱导的免疫力的持久性有相当大的影响。在这里，我们监测了症状发作后15个月随访的COVID-19患者的SARS-CoV-2特异性免疫应答。在感染后第15-28天达到峰值后，IgG抗体应答和血浆中和滴度随时间逐渐下降，但在6个月后稳定。与G614相比，针对变体β、γ和δ的血浆中和滴度低8倍以上。SARS-CoV-2特异性记忆B和T细胞在大多数患者中持续长达15个月，尽管在6至15个月之间观察到特异性T细胞显著减少，但B细胞没有减少。抗病毒特异性免疫，特别是COVID-19恢复期患者的记忆B细胞，是持久的，但一些令人担忧的变异体可能至少部分逃脱了血浆抗体的中和活性。大多数患者的血浆中和抗体持续存在长达15个月针对所关注的变体Delta、Beta和Gamma的中和活性较低长达15个月95%的患者中存在特异性记忆B和T细胞特异性T细胞，但不存在B细胞，在6至15个月之间减少免疫学;免疫应答;病毒学
Information concerning the longevity of immunity to SARS-CoV-2 following natural infection may have considerable implications for durability of immunity induced by vaccines. Here, we monitored the SARS-CoV-2 specific immune response in COVID-19 patients followed up to 15 months after symptoms onset. Following a peak at day 15–28 postinfection, the IgG antibody response and plasma neutralizing titers gradually decreased over time but stabilized after 6 months. Compared to G614, plasma neutralizing titers were more than 8-fold lower against variants Beta, Gamma, and Delta. SARS-CoV-2-specific memory B and T cells persisted in the majority of patients up to 15 months although a significant decrease in specific T cells, but not B cells, was observed between 6 and 15 months. Antiviral specific immunity, especially memory B cells in COVID-19 convalescent patients, is long-lasting, but some variants of concern may at least partially escape the neutralizing activity of plasma antibodies. Plasma neutralizing antibodies persist in the majority of patients up to 15 months Neutralizing activity is lower against variants of concern Delta, Beta, and Gamma Specific memory B and T cells were present in 95% of patients up to 15 months Specific T cells, but not B cells, were decreased between 6 and 15 months Immunology; Immune response; Virology
登录
查看更多内容
DOI：
10.1016/j.xcrm.2021.100290
发表时间：
2021-06-15
期刊：
Cell reports. Medicine
影响因子：
--
作者：
Anand SP;Prévost J;Nayrac M;Beaudoin-Bussières G;Benlarbi M;Gasser R;Brassard N;Laumaea A;Gong SY;Bourassa C;Brunet-Ratnasingham E;Medjahed H;Gendron-Lepage G;Goyette G;Gokool L;Morrisseau C;Bégin P;Martel-Laferrière V;Tremblay C;Richard J;Bazin R;Duerr R;Kaufmann DE;Finzi A
通讯作者：
Finzi A
SARS-COV-2血统的估计可传播和影响B.1.1.7在英国。
DOI：
10.1126/science.abg3055
发表时间：
2021-04-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Davies NG;Abbott S;Barnard RC;Jarvis CI;Kucharski AJ;Munday JD;Pearson CAB;Russell TW;Tully DC;Washburne AD;Wenseleers T;Gimma A;Waites W;Wong KLM;van Zandvoort K;Silverman JD;CMMID COVID-19 Working Group;COVID-19 Genomics UK (COG-UK) Consortium;Diaz-Ordaz K;Keogh R;Eggo RM;Funk S;Jit M;Atkins KE;Edmunds WJ
通讯作者：
Edmunds WJ
影响因子：
9.4
作者：
Addetia A;Crawford KHD;Dingens A;Zhu H;Roychoudhury P;Huang ML;Jerome KR;Bloom JD;Greninger AL
通讯作者：
Greninger AL
DOI：
10.3390/v13050794
发表时间：
2021-04-29
期刊：
Viruses
影响因子：
--
作者：
Di Giallonardo F;Puglia I;Curini V;Cammà C;Mangone I;Calistri P;Cobbin JCA;Holmes EC;Lorusso A
通讯作者：
Lorusso A
DOI：
10.1056/nejmoa2109072
发表时间：
2021-10-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
Bergwerk M;Gonen T;Lustig Y;Amit S;Lipsitch M;Cohen C;Mandelboim M;Levin EG;Rubin C;Indenbaum V;Tal I;Zavitan M;Zuckerman N;Bar-Chaim A;Kreiss Y;Regev-Yochay G
通讯作者：
Regev-Yochay G