Bile Acid Receptors and the Gut-Liver Axis in Nonalcoholic Fatty Liver Disease.
Bile Acid Receptors and the Gut-Liver Axis in Nonalcoholic Fatty Liver Disease.
复制标题
非酒精性脂肪肝的胆汁酸受体和肠-肝轴
作者：
Xue R;Su L;Lai S;Wang Y;Zhao D;Fan J;Chen W;Hylemon PB;Zhou H
The prevalence of nonalcoholic fatty liver disease (NAFLD) has been significantly increased due to the global epidemic of obesity. The disease progression from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH) is closely linked to inflammation, insulin resistance, and dysbiosis. Although extensive efforts have been aimed at elucidating the pathological mechanisms of NAFLD disease progression, current understanding remains incomplete, and no effective therapy is available. Bile acids (BAs) are not only important physiological detergents for the absorption of lipid-soluble nutrients in the intestine but also metabolic regulators. During the last two decades, BAs have been identified as important signaling molecules involved in lipid, glucose, and energy metabolism. Dysregulation of BA homeostasis has been associated with NAFLD disease severity. Identification of nuclear receptors and G-protein-coupled receptors activated by different BAs not only significantly expanded the current understanding of NAFLD/NASH disease progression but also provided the opportunity to develop potential therapeutics for NAFLD/NASH. In this review, we will summarize the recent studies with a focus on BA-mediated signaling pathways in NAFLD/NASH. Furthermore, the therapeutic implications of targeting BA-mediated signaling pathways for NAFLD will also be discussed.
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DOI：
10.1073/pnas.2007856117
发表时间：
2020-09-29
影响因子：
11.1
作者：
Aji G;Huang Y;Ng ML;Wang W;Lan T;Li M;Li Y;Chen Q;Li R;Yan S;Tran C;Burchfield JG;Couttas TA;Chen J;Chung LH;Liu D;Wadham C;Hogg PJ;Gao X;Vadas MA;Gamble JR;Don AS;Xia P;Qi Y
通讯作者：
Qi Y
影响因子：
4.6
作者：
Carino A;Cipriani S;Marchianò S;Biagioli M;Santorelli C;Donini A;Zampella A;Monti MC;Fiorucci S
通讯作者：
Fiorucci S
DOI：
10.1111/febs.12446
发表时间：
2013-12
期刊：
The FEBS journal
影响因子：
--
作者：
Adada M;Canals D;Hannun YA;Obeid LM
通讯作者：
Obeid LM
影响因子：
--
作者：
Chen X;Lou G;Meng Z;Huang W
通讯作者：
Huang W
影响因子：
5.8
作者：
Chiang JY
通讯作者：
Chiang JY