Superior longitudinal fasciculus and language functioning in healthy aging.
Superior longitudinal fasciculus and language functioning in healthy aging.
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DOI：
10.1016/j.brainres.2014.03.012
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发表时间：
2014-05-08
期刊：
影响因子：
2.9
通讯作者：
Szaflarski, Jerzy
中科院分区：
文献类型：
--
作者：
Madhavan, Kiely M.;McQueeny, Tim;Howe, Steven R.;Shear, Paula;Szaflarski, Jerzy
老年人脑组织的结构性退化被认为是大多数与年龄相关的认知能力下降的原因。由于轴突完整性的丧失，广泛的皮质网络中断也可能发挥重要作用。研究结构变化和功能衰退之间的相关性的研究主要集中在工作记忆、处理速度和执行过程上，而认知的其他方面，例如语言功能，受到的关注较少。本研究旨在确定上级纵束（SLF）的年龄相关变化是否是与年龄相关的语言功能恶化的原因。受试者包括112名右撇子志愿者（年龄19-76岁）。对于每个受试者，从扩散张量图像（DTI）重建左半球的SLF。平均分数各向异性（FA）值提取顶骨（SLFP）和颞（SLFt）束。使用皮博迪图片词汇测试（PPVT），波士顿词汇测试（BNT），控制性口语词汇联想测试（COWAT）和语义流畅性测试（SFT）测量语言功能。回归分析显示，男性和女性在成年期表现出不同的FA下降模式。对于男性，更大的SLFt FA与COWAT性能的增加显著相关，年龄和SLFp FA与BNT评分之间存在正相关关系。在女性中，较大的SLFP FA与较低的COWAT性能相关。两者合计，结果表明，白色物质完整性的SLF遵循不同的模式下降，在成年男性和女性，这种下降差异影响语言功能。
Structural deterioration of brain tissue in older adults is thought to be responsible for the majority of age-related cognitive decline. Disruption of widespread cortical networks due to a loss of axonal integrity may also play an important role. Research examining correlations between structural change and functional decline has focused heavily on working memory, processing speed, and executive processes while other aspects of cognition, such as language functioning, have received less attention. The current study aimed to determine whether age-related changes in the superior longitudinal fasciculus (SLF), are responsible for the deterioration in language functioning associated with age. Subjects included 112 right-handed volunteers (ages 19–76). For each subject, the SLF of the left hemisphere was reconstructed from diffusion tensor images (DTI). Mean fractional anisotropy (FA) values were extracted from parietal (SLFp) and temporal (SLFt) bundles. Language functioning was measured using the Peabody Picture Vocabulary Test (PPVT), Boston Naming Test (BNT), Controlled Oral Word Association Test (COWAT), and Semantic Fluency Test (SFT). Regression analyses revealed that males and females showed a different pattern of decline in FA across adulthood. For males, greater SLFt FA was significantly associated with increased COWAT performance, and there was a positive relationship between both age and SLFp FA with BNT scores. In females, greater SLFp FA was related to lower COWAT performance. Taken together, the results suggest that white matter integrity of the SLF follows a different pattern of decline in adulthood for males and females, and this decline differentially affects language functioning.
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影响因子：
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