Silicone wristbands compared with traditional polycyclic aromatic hydrocarbon exposure assessment methods.
Silicone wristbands compared with traditional polycyclic aromatic hydrocarbon exposure assessment methods.
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DOI：
10.1007/s00216-018-0992-z
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发表时间：
2018-05
影响因子：
4.3
通讯作者：
Anderson KA
中科院分区：
文献类型：
--
作者：
Dixon HM;Scott RP;Holmes D;Calero L;Kincl LD;Waters KM;Camann DE;Calafat AM;Herbstman JB;Anderson KA
目前缺乏廉价、易于使用的技术来评估人类接触环境化学品的情况，包括多环芳烃。这是第一项将硅胶腕带与两种传统的个人PAH暴露评估方法一起部署的研究：使用采样器进行主动空气监测（即，聚氨酯泡沫（PUF）和过滤器），并使用尿液进行生物采样。我们表明，腕带佩戴48小时在非职业环境中恢复半挥发性多环芳烃，我们比较多环芳烃的多环芳烃在多不饱和脂肪酸过滤器和羟基-多环芳烃（OH-PAH）的生物标志物在尿液中的腕带水平。我们部署所有采样器同时为48小时的22名孕妇在一个既定的城市出生队列。每名妇女在48小时结束时提供一份现场尿样。腕带回收多环芳烃与类似的检测频率的PUF过滤器。在22个腕带中检测的62种多环芳烃中，至少在一个腕带中检测到51种多环芳烃。在这组孕妇中，我们发现腕带中的OH-PAH和PAH之间的相关性比PUF过滤器中的OH-PAH和PAH之间的相关性更显著。在PUFs过滤器中的多环芳烃和OH-PAH之间只有两个比较显著相关（rs = 0.53和p = 0.01; rs = 0.44和p = 0.04），而腕带中的多环芳烃和OH-PAH之间的六个比较显著相关（rs = 0.44至0.76和p = 0.04至<0.0001）。这些结果支持腕带作为生物相关的暴露评估工具，可以很容易地集成到环境健康研究的效用。从城市孕妇采集的样本中检测到的多环芳烃本文的在线版本（10. 1007/s 00216 -018-0992-z）包含补充材料，可供授权用户使用。
Currently there is a lack of inexpensive, easy-to-use technology to evaluate human exposure to environmental chemicals, including polycyclic aromatic hydrocarbons (PAHs). This is the first study in which silicone wristbands were deployed alongside two traditional personal PAH exposure assessment methods: active air monitoring with samplers (i.e., polyurethane foam (PUF) and filter) housed in backpacks, and biological sampling with urine. We demonstrate that wristbands worn for 48 h in a non-occupational setting recover semivolatile PAHs, and we compare levels of PAHs in wristbands to PAHs in PUFs-filters and to hydroxy-PAH (OH-PAH) biomarkers in urine. We deployed all samplers simultaneously for 48 h on 22 pregnant women in an established urban birth cohort. Each woman provided one spot urine sample at the end of the 48-h period. Wristbands recovered PAHs with similar detection frequencies to PUFs-filters. Of the 62 PAHs tested for in the 22 wristbands, 51 PAHs were detected in at least one wristband. In this cohort of pregnant women, we found more significant correlations between OH-PAHs and PAHs in wristbands than between OH-PAHs and PAHs in PUFs-filters. Only two comparisons between PAHs in PUFs-filters and OH-PAHs correlated significantly (rs = 0.53 and p = 0.01; rs = 0.44 and p = 0.04), whereas six comparisons between PAHs in wristbands and OH-PAHs correlated significantly (rs = 0.44 to 0.76 and p = 0.04 to <0.0001). These results support the utility of wristbands as a biologically relevant exposure assessment tool which can be easily integrated into environmental health studies. PAHs detected in samples collected from urban pregnant women The online version of this article (10.1007/s00216-018-0992-z) contains supplementary material, which is available to authorized users.
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影响因子：
11.4
作者：
Hammel SC;Hoffman K;Webster TF;Anderson KA;Stapleton HM
通讯作者：
Stapleton HM
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10.4
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通讯作者：
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影响因子：
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作者：
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Honkoop, Pieter J. C.
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影响因子：
9.8
作者：
Ge, Linke;Na, Guangshui;Yao, Ziwei
通讯作者：
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