Olfactory impairment in Wilson's disease.
Olfactory impairment in Wilson's disease.
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威尔逊病的嗅觉障碍
DOI：
10.1002/brb3.2022
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发表时间：
2021-03
影响因子：
3.1
通讯作者：
Yan X
中科院分区：
文献类型：
--
作者：
Chen L;Wang X;Doty RL;Cao S;Yang J;Sun F;Yan X
嗅觉功能障碍是许多神经退行性疾病的常见和早期体征，但对Wilson病（WD）的嗅觉功能障碍知之甚少。我们的目的是评估WD患者的嗅觉功能，并确定选择性WD筛选气味。我们使用宾夕法尼亚大学嗅觉识别测试（UPSIT）对25例WD患者和25例健康对照者的嗅觉识别能力进行了测量。采用WD总体评估量表（GAS）对WD患者进行评估。认知功能的测量使用简易精神状态检查。WD患者在简体中文版UPSIT中识别气味的能力比健康对照组差（t = 2.198，p = 0.033），但两组之间的嗅觉功能障碍严重程度没有差异（V = 136，p = 0.094）。WD患者的UPSIT评分与GAS神经功能评分呈负相关（r =-0.571，p = .003）。使用最小绝对收缩的逻辑回归和选择算子分析，筛选两个模型。受试者操作特征（ROC）曲线分析显示，为了区分WD患者和健康对照，七种气味（机油、洋葱、甘草、草莓、轮胎、茉莉和天然气）组合的ROC曲线下面积（AUC）为0.926，而三种气味（洋葱、甘草和茉莉）的AUC为0.852。WD患者可能有稳定的、选择性的嗅觉障碍。这种选择性模式可能是疾病诊断和预测的有用工具。WD患者的嗅觉功能和选择性气味识别障碍已被探讨。我们发现，与健康对照组相比，WD患者识别气味的能力较差，但嗅觉减退的严重程度比PD或AD患者轻。在WD中也检测到嗅觉功能障碍的选择性模式，并且七种气味模型和三种气味模型都表现出良好的疾病判别准确性。
Olfactory dysfunction is a common and early sign of many neurodegenerative disorders, but little is known about olfactory dysfunction in Wilson’s disease (WD). We aimed to evaluate olfactory function in patients with WD and identify selective WD screening odors. We measured olfactory identification ability in 25 patients with WD and 25 healthy controls using the University of Pennsylvania Smell Identification Test (UPSIT). Patients with WD were evaluated using the Global Assessment Scale for WD (GAS). Cognitive function was measured using the Mini–Mental State Examination. Patients with WD were worse at identifying smells in the simplified Chinese version of the UPSIT compared with healthy controls (t = 2.198, p = .033), but there was no difference in olfactory dysfunction severity between the groups (V = 136, p = .094). UPSIT scores negatively correlated with the GAS neurological scores in patients with WD (r = −0.571, p = .003). Using logistic regression with least absolute shrinkage and selection operator analysis, two models were screened. Receiver‐operating characteristic (ROC) curve analysis revealed that, to discriminate WD patients from healthy controls, the area under the ROC curve (AUC) for a combination of seven odors (motor oil, onion, licorice, strawberry, tire, jasmine, and natural gas) was 0.926, while the AUC for three odors (onion, licorice, and jasmine) was 0.852. Patients with WD may have stable, selective olfactory impairments. This selective pattern may be a useful tool for disease diagnosis and prediction. Olfactory function and selective odor identification impairment has been explored in patients with WD. We found that the patients with WD were worse at identifying smells compared with healthy controls, but the hyposmia severity was milder than that found in PD or AD patients. A selective pattern of olfactory dysfunction was also detected in WD, and both the seven odor model and the three odor model showed good disease discrimination accuracy.
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DOI：
10.1016/s1474-4422(14)70190-5
发表时间：
2015-01
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Bandmann O;Weiss KH;Kaler SG
通讯作者：
Kaler SG
DOI：
10.1080/13803395.2013.809701
发表时间：
2013
影响因子：
2.2
作者：
Schubert CR;Cruickshanks KJ;Fischer ME;Huang GH;Klein R;Pankratz N;Zhong W;Nondahl DM
通讯作者：
Nondahl DM
影响因子：
8.6
作者：
Boesveldt, Sanne;Verbaan, Dagmar;Berendse, Henk W.
通讯作者：
Berendse, Henk W.
影响因子：
2
作者：
Meenakshi-Sundaram, S.;Mahadevan, A.;Shankar, S. K.
通讯作者：
Shankar, S. K.
影响因子：
2.6
作者：
Degirmenci, Nazan;Veyseller, Bayram;Ozturan, Orhan
通讯作者：
Ozturan, Orhan