Electrophysiological assessment of temporal envelope processing in cochlear implant users.
Electrophysiological assessment of temporal envelope processing in cochlear implant users.
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DOI：
10.1038/s41598-020-72235-9
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发表时间：
2020-09-21
影响因子：
4.6
通讯作者：
Wouters J
中科院分区：
文献类型：
--
作者：
Gransier R;Carlyon RP;Wouters J
耳蜗植入（CI）用户依赖于时间包络调制（TEM）来理解语音，临床结果取决于这些TEM被电刺激神经系统编码的准确性。这种编码的非侵入性EEG测量可以帮助临床医生识别和禁用引起不良神经反应的电极，以改善CI结果。然而，在CI刺激期间记录EEG揭示了比神经响应大几个数量级的巨大刺激伪影。在这里，我们使用了一个定制的EEG系统，具有非常高的采样率，以准确地测量伪影，然后我们使用线性插值删除，以揭示连续电刺激过程中的神经反应。在10名成年CI用户中，我们测量了40 Hz电诱发听觉稳态反应（eASSR）和电诱发听觉变化复合波（eACC），以调幅900脉冲每秒脉冲串，刺激单极模式（即临床默认），并在不同的调制深度。我们成功测量了无伪影的40 Hz eASSR和eACC。此外，我们发现，40-Hz的eASSR，与eACC相反，即使在浅调制深度也显示出实质性的响应。我们认为，40-Hz的eASSR是一个临床上可行的客观措施，以评估TEM编码CI用户。
Cochlear-implant (CI) users rely on temporal envelope modulations (TEMs) to understand speech, and clinical outcomes depend on the accuracy with which these TEMs are encoded by the electrically-stimulated neural ensembles. Non-invasive EEG measures of this encoding could help clinicians identify and disable electrodes that evoke poor neural responses so as to improve CI outcomes. However, recording EEG during CI stimulation reveals huge stimulation artifacts that are up to orders of magnitude larger than the neural response. Here we used a custom-built EEG system having an exceptionally high sample rate to accurately measure the artefact, which we then removed using linear interpolation so as to reveal the neural response during continuous electrical stimulation. In ten adult CI users, we measured the 40-Hz electrically evoked auditory steady-state response (eASSR) and electrically evoked auditory change complex (eACC) to amplitude-modulated 900-pulses-per-second pulse trains, stimulated in monopolar mode (i.e. the clinical default), and at different modulation depths. We successfully measured artifact-free 40-Hz eASSRs and eACCs. Moreover, we found that the 40-Hz eASSR, in contrast to the eACC, showed substantial responses even at shallow modulation depths. We argue that the 40-Hz eASSR is a clinically feasible objective measure to assess TEM encoding in CI users.
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影响因子：
3.7
作者：
He S;Grose JH;Teagle HF;Woodard J;Park LR;Hatch DR;Buchman CA
通讯作者：
Buchman CA
DOI：
10.1109/tnsre.2016.2622979
发表时间：
2017-08-01
影响因子：
4.9
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
van Wieringen A
影响因子：
3.7
作者：
Gransier, Robin;van Wieringen, Astrid;Wouters, Jan
通讯作者：
Wouters, Jan
影响因子：
3.7
作者：
Dimitrijevic, Andrew;Alsamri, Jamal;Zeng, Fan-Gang
通讯作者：
Zeng, Fan-Gang