Barriers and Breakthroughs in Targeting the Oxytocin System to Treat Alcohol Use Disorder.
Barriers and Breakthroughs in Targeting the Oxytocin System to Treat Alcohol Use Disorder.
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DOI：
10.3389/fpsyt.2022.842609
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发表时间：
2022
影响因子：
4.7
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Ryabinin AE;Zhang Y
迫切需要开发更好的治疗酒精使用障碍（AUD）的方法。这种发展的一个有希望的机会是针对催产素肽系统的潜力。临床前研究表明，在几种啮齿类动物模型中，外源性催产素或最近刺激表达内源性催产素的神经元可导致酒精消耗减少。初步的临床研究还表明，催产素的使用减少了对酒精和大量饮酒的渴望。然而，最近的几项临床研究无法复制这些效果。因此，尽管靶向催产素系统有望治疗AUD，但需要更细致入微的方法来开发和应用这些治疗方法。在这篇小型综述中，我们讨论了在临床研究中使用催产素调节酒精使用障碍相关行为的不同成功的潜在警告，并评估了针对催产素系统可以改进的三个方向：(1)增加外源性催产素的效价，(2)开发催产素受体激动剂，(3)刺激内源性催产素系统的成分。讨论了这些方向的进展和潜在的缺陷。
Development of better treatments for alcohol use disorder (AUD) is urgently needed. One promising opportunity for this development is the potential of targeting the oxytocin peptide system. Preclinical studies showed that administration of exogenous oxytocin or, more recently, stimulation of neurons expressing endogenous oxytocin lead to a decreased alcohol consumption across several rodent models. Initial clinical studies also showed that administration of oxytocin decreased craving for alcohol and heavy alcohol drinking. However, several more recent clinical studies were not able to replicate these effects. Thus, although targeting the oxytocin system holds promise for the treatment of AUD, more nuanced approaches toward development and application of these treatments are needed. In this mini-review we discuss potential caveats resulting in differential success of attempts to use oxytocin for modulating alcohol use disorder-related behaviors in clinical studies and evaluate three directions in which targeting the oxytocin system could be improved: (1) increasing potency of exogenously administered oxytocin, (2) developing oxytocin receptor agonists, and (3) stimulating components of the endogenous oxytocin system. Both advances and potential pitfalls of these directions are discussed.
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影响因子：
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作者：
Freeman SM;Young LJ
通讯作者：
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DOI：
10.3390/ijerph182111130
发表时间：
2021-10-22
影响因子：
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作者：
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发表时间：
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影响因子：
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作者：
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影响因子：
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作者：
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