Making the rich richer: Frontoparietal tDCS enhances transfer effects of a single-session distractor inhibition training on working memory in high capacity individuals but reduces them in low capacity individuals
Making the rich richer: Frontoparietal tDCS enhances transfer effects of a single-session distractor inhibition training on working memory in high capacity individuals but reduces them in low capacity individuals
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让富人更富：额顶 tDCS 增强了单次分心抑制训练对高能力个体工作记忆的转移效应，但降低了低能力个体的转移效应
DOI：
10.1016/j.neuroimage.2021.118438
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发表时间：
2021
期刊：
影响因子：
5.7
通讯作者：
Müller NG
中科院分区：
文献类型：
--
作者：
Schmicker M;Menze I;Schneider C;Taubert M;Zaehle T;Müller NG
工作记忆（WM）的性能取决于提取相关信息同时抑制不相关信息进入WM存储的能力。这种干扰抑制能力是可以训练的，并且已知会诱导WM表现的转移效应。在这里，我们询问在单次干扰物抑制训练中，经颅直流电刺激（tDCS）是否可以促进WM上的转移。由于WM表现归因于额顶叶网络，其中前额叶区域与抑制干扰物有关，后顶叶区域与存储信息有关，我们在单次干扰物抑制训练中将阳极置于前额叶上，阴极置于后顶叶皮层上。这种网络导向的刺激方案应该通过将神经活动从后脑区转移到前额叶区来增强抑制过程。在verum刺激下进行单次分心物抑制训练后，WM得到改善，但仅在具有高WM能力的受试者中得到改善。在脑记忆能力低的受试者中，verum tDCS降低了脑记忆的转移效应。我们假设tDCS可以增强具有高WM能力的个体的额纹状体通路，从而有效抑制干扰物。相反，后顶叶皮层的阴极刺激可能阻碍了低容量受试者通常的代偿机制，即在记忆中保持不相关的信息。因此，我们的结果强调需要调整tDCS协议，以充分了解神经网络和个体认知差异。
Working memory (WM) performance depends on the ability to extract relevant while inhibiting irrelevant information from entering the WM storage. This distractor inhibition ability can be trained and is known to induce transfer effects on WM performance. Here we asked whether transfer on WM can be boosted by transcranial direct current stimulation (tDCS) during a single-session distractor inhibition training. As WM performance is ascribed to the frontoparietal network, in which prefrontal areas are associated with inhibiting distractors and posterior parietal areas with storing information, we placed the anode over the prefrontal and the cathode over the posterior parietal cortex during a single-session distractor inhibition training. This network-oriented stimulation protocol should enhance inhibition processes by shifting the neural activity from posterior to prefrontal regions. WM improved after a single-session distractor inhibition training under verum stimulation but only in subjects with a high WM capacity. In subjects with a low WM capacity, verum tDCS reduced the transfer effects on WM. We assume tDCS to strengthen the frontostriatal pathway in individuals with a high WM capacity leading to efficient inhibition of distractors. In contrast, the cathodal stimulation of the posterior parietal cortex might have hindered usual compensational mechanism in low capacity subjects, i.e. maintaining also irrelevant information in memory. Our results thus stress the need to adjust tDCS protocols to well-founded knowledge about neural networks and individual cognitive differences.
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影响因子：
3.2
作者：
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通讯作者：
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