Predictors of HIV infection and prevalence for syphilis infection among injection drug users in China: community-based surveys along major drug trafficking routes.
Predictors of HIV infection and prevalence for syphilis infection among injection drug users in China: community-based surveys along major drug trafficking routes.
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DOI：
10.1186/1477-7517-5-29
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发表时间：
2008-08-25
影响因子：
4.4
通讯作者：
Vermund SH
中科院分区：
文献类型：
--
作者：
Jia Y;Lu F;Zeng G;Sun X;Xiao Y;Lu L;Liu W;Ni M;Qu S;Li C;Liu J;Wu P;Vermund SH
评估中国三省主要贩毒路线沿着高度流行地区注射吸毒者中艾滋病毒感染的预测因素和流行率。我们通过社区外展和同行推荐招募参与者。基于uestionnaire的访谈提供了人口统计学、药物使用和性行为信息。HIV检测采用ELISA法，梅毒检测采用RPR法。在689名参与者中，51.8%为HIV感染者，广西人的感染率（16.4%）显著低于新疆和云南人（分别为66.8%和67.1%）。梅毒血清阳性率为5.4%。多因素分析显示，长期吸毒、对HIV传播途径了解较多、居住在新疆或云南与HIV血清阳性相关。不同研究中心的独立风险因素不同。在广西，男性和长期注射毒品是HIV感染的独立危险因素;在新疆，年龄较大和共用针头和/或注射器是HIV感染的独立危险因素;在云南，更频繁的毒品注射、对HIV传播途径更高的认识和更高的收入是HIV血清阳性的独立预测因素。中国注射吸毒人群中艾滋病病毒感染率在某些场所超过三分之二。风险因素包括注射吸毒时间较长和共用针头。与艾滋病毒有关的还有一些因素，可能表明在高危人群中的教育取得了一些成功，如较高的知识。在中国，一个系统的社区层面干预措施应包括针具交换、基于阿片类药物的药物治疗、安全套分发沿着宣传，以及倡导以社区为基础的VCT，并将其与艾滋病毒预防服务和护理联系起来。
To assess the predictors and prevalence of HIV infection among injection drug users in highly endemic regions along major drug trafficking routes in three Chinese provinces. We enrolled participants using community outreach and peer referrals. uestionnaire-based interviews provided demographic, drug use, and sexual behavior information. HIV was tested via ELISA and syphilis by RPR. Of the 689 participants, 51.8% were HIV-infected, with persons living in Guangxi having significantly lower prevalence (16.4%) than those from Xinjiang and Yunnan (66.8% and 67.1%, respectively). Syphilis seropositivity was noted in 5.4%. Longer duration of IDU, greater awareness of HIV transmission routes, and living in Xinjiang or Yunnan were associated with HIV seropositivity on multivariable analysis. Independent risk factors differed between sites. In Guangxi, being male and having a longer duration of IDU were independent risk factors for HIV infection; in Xinjiang, older age and sharing needles and/or syringes were independent factors; in Yunnan, more frequent drug injection, greater awareness of HIV transmission routes, and higher income were independent predictors of HIV seropositivity. Prevalence rates of HIV among IDUs in China are more than two out of three in some venues. Risk factors include longer duration of IDU and needle sharing. Also associated with HIV were factors that may indicate some success in education in higher risk persons, such as higher knowledge. A systemic community-level intervention with respect to evidenced-based, population-level interventions to stem the spread of HIV from IDU in China should include needle exchange, opiate agonist-based drug treatment, condom distribution along with promotion, and advocacy for community-based VCT with bridges to HIV preventive services and care.
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影响因子：
5
作者：
LEVINE, OS;VLAHOV, D;NELSON, KE
通讯作者：
NELSON, KE
影响因子：
3.1
作者：
Liu, HJ;Grusky, O;Ma, EJ
通讯作者：
Ma, EJ
影响因子：
5
作者：
FRIEDMAN, SR;JOSE, B;NEAIGUS, A
通讯作者：
NEAIGUS, A
DOI：
10.1196/annals.1316.055
发表时间：
2004-01-01
期刊：
CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY
影响因子：
--
作者：
Kulsudjarit, K
通讯作者：
Kulsudjarit, K
影响因子：
4.4
作者：
Qian HZ;Schumacher JE;Chen HT;Ruan YH
通讯作者：
Ruan YH