Asymmetric cell division of stem and progenitor cells during homeostasis and cancer.
Asymmetric cell division of stem and progenitor cells during homeostasis and cancer.
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DOI：
10.1007/s00018-013-1386-1
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发表时间：
2014-02
影响因子：
8
通讯作者：
Petritsch, Claudia
中科院分区：
文献类型：
--
作者：
Gomez-Lopez, Sandra;Lerner, Robin G.;Petritsch, Claudia
关键词：
干细胞和祖细胞的特征在于其自我更新和产生分化后代的能力。这些过程之间的良好平衡是通过受控的不对称分裂来实现的，并且是在发育期间产生细胞多样性和维持成体组织稳态所必需的。这种平衡的破坏可能导致干/祖细胞库的过早耗尽或异常生长。在许多组织中，包括大脑，失调的不对称分裂与癌症有关。不对称细胞分裂缺陷和癌症发生之间是否存在因果关系尚不清楚。在这里，我们回顾了调节神经谱系中不对称细胞分裂的细胞和分子机制，并讨论了这种调节机制与癌症之间的潜在联系。
Stem and progenitor cells are characterized by their ability to self-renew and produce differentiated progeny. A fine balance between these processes is achieved through controlled asymmetric divisions and is necessary to generate cellular diversity during development and to maintain adult tissue homeostasis. Disruption of this balance may result in premature depletion of the stem/progenitor cell pool, or abnormal growth. In many tissues, including the brain, dysregulated asymmetric divisions are associated with cancer. Whether there is a causal relationship between asymmetric cell division defects and cancer initiation is as yet not known. Here, we review the cellular and molecular mechanisms that regulate asymmetric cell divisions in the neural lineage and discuss the potential connections between this regulatory machinery and cancer.
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影响因子：
16.2
作者：
Bultje, Ronald S.;Castaneda-Castellanos, David R.;Jan, Lily Yen;Jan, Yuh-Nung;Kriegstein, Arnold R.;Shi, Song-Hai
通讯作者：
Shi, Song-Hai
影响因子：
11.2
作者：
Bonavia R;Inda MM;Cavenee WK;Furnari FB
通讯作者：
Furnari FB
影响因子：
64.8
作者：
Betschinger, J;Mechtler, K;Knoblich, JA
通讯作者：
Knoblich, JA
影响因子：
2.7
作者：
Chabu, Chiswili;Doe, Chris Q.
通讯作者：
Doe, Chris Q.
影响因子：
30.8
作者：
Caussinus, E;Gonzalez, C
通讯作者：
Gonzalez, C