Altered genome-wide hippocampal gene expression profiles following early life lead exposure and their potential for reversal by environmental enrichment.
Altered genome-wide hippocampal gene expression profiles following early life lead exposure and their potential for reversal by environmental enrichment.
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DOI：
10.1038/s41598-022-15861-9
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发表时间：
2022-07-25
影响因子：
4.6
通讯作者：
Schneider, J. S.
中科院分区：
文献类型：
--
作者：
Singh, G.;Singh, V;Kim, T.;Ertel, A.;Fu, W.;Schneider, J. S.
早期铅暴露对神经行为发育有害。环境质量可以改变铅暴露的负面影响，影响铅暴露后的发展轨迹。关于大脑中铅和环境质量之间相互作用的分子基础知之甚少。我们研究了早期生活铅暴露和生活在一个丰富的与非丰富的出生后环境的海马CA 1区全基因组转录谱之间的关系。RNA-seq鉴定了富集与非富集Pb暴露动物的转录组的差异。大多数与铅暴露相关的基因表达变化被富集逆转。这也适用于上游调控因子、剪接事件和长非编码RNA的变化。非富集大鼠也有记忆障碍;富集大鼠没有缺陷。结果表明，丰富的环境对行为和Pb修饰的CA 1转录组具有深远的影响。这些研究结果表明，铅暴露和环境之间的相互作用，导致显着的转录变化在大脑中，并在一定程度上，这可能会发生在铅暴露的儿童，可能会影响神经心理/教育成果，强调早期干预和环境富集铅暴露的儿童的重要性。
Early life lead (Pb) exposure is detrimental to neurobehavioral development. The quality of the environment can modify negative influences from Pb exposure, impacting the developmental trajectory following Pb exposure. Little is known about the molecular underpinnings in the brain of the interaction between Pb and the quality of the environment. We examined relationships between early life Pb exposure and living in an enriched versus a non-enriched postnatal environment on genome-wide transcription profiles in hippocampus CA1. RNA-seq identified differences in the transcriptome of enriched vs. non-enriched Pb-exposed animals. Most of the gene expression changes associated with Pb exposure were reversed by enrichment. This was also true for changes in upstream regulators, splicing events and long noncoding RNAs. Non-enriched rats also had memory impairments; enriched rats had no deficits. The results demonstrate that an enriched environment has a profound impact on behavior and the Pb-modified CA1 transcriptome. These findings show the potential for interactions between Pb exposure and the environment to result in significant transcriptional changes in the brain and, to the extent that this may occur in Pb-exposed children, could influence neuropsychological/educational outcomes, underscoring the importance for early intervention and environmental enrichment for Pb-exposed children.
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影响因子：
30.8
作者：
Durand, Christelle M.;Betancur, Catalina;Bourgeron, Thomas
通讯作者：
Bourgeron, Thomas
影响因子：
3.1
作者：
Gu, Wei;Gao, Tian;Hu, Meijie
通讯作者：
Hu, Meijie
DOI：
10.1186/s12940-015-0008-9
发表时间：
2015-04-07
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Evens A;Hryhorczuk D;Lanphear BP;Rankin KM;Lewis DA;Forst L;Rosenberg D
通讯作者：
Rosenberg D
影响因子：
11.2
作者：
Guilarte, TR;Toscano, CD;Weaver, SA
通讯作者：
Weaver, SA
突触前电压门控钙通道的功能。
DOI：
10.1093/function/zqaa027
发表时间：
2021
期刊：
Function (Oxford, England)
影响因子：
--
作者：
Dolphin AC
通讯作者：
Dolphin AC