B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity.
B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity.
复制标题
DOI：
10.1016/j.immuni.2012.01.013
复制
发表时间：
2012-03-23
期刊：
影响因子：
32.4
通讯作者：
von Andrian UH
中科院分区：
文献类型：
--
作者：
Moseman EA;Iannacone M;Bosurgi L;Tonti E;Chevrier N;Tumanov A;Fu YX;Hacohen N;von Andrian UH
中和抗体被认为是保护免受急性细胞病变病毒，如嗜神经性水泡性口炎病毒（VSV）所需的。利用具有B细胞但缺乏抗体的小鼠，我们在此显示皮下（s.c.）VSV攻击是独立的中和抗体的产生或细胞介导的适应性免疫。然而，B细胞绝对需要提供光毒素（LT）α1β2，其在病毒引流淋巴结（LN）内维持保护性被膜下窦（SCS）巨噬细胞表型。B细胞缺陷型LN或B细胞中选择性缺乏LTα1β2的小鼠SCS内的巨噬细胞显示异常表型，不能复制VSV，因此不能产生I型干扰素，而I型干扰素是防止致命性VSV侵入结内神经所必需的。因此，尽管B细胞对于VSV感染期间的存活是必不可少的，但它们的贡献涉及向巨噬细胞提供先天分化和维持信号，而不是适应性免疫机制。
Neutralizing antibodies have been thought to be required for protection against acutely cytopathic viruses, such as the neurotropic vesicular stomatitis virus (VSV). Utilizing mice that possess B cells but lack antibodies, we show here that survival upon subcutaneous (s.c.) VSV challenge was independent of neutralizing antibody production or cell-mediated adaptive immunity. However, B cells were absolutely required to provide lymphotoxin (LT) α1β2, which maintained a protective subcapsular sinus (SCS) macrophage phenotype within virus draining lymph nodes (LNs). Macrophages within the SCS of B cell-deficient LNs, or of mice that lack LTα1β2 selectively in B cells, displayed an aberrant phenotype, failed to replicate VSV, and therefore did not produce type I interferons, which were required to prevent fatal VSV invasion of intranodal nerves. Thus, although B cells are essential for survival during VSV infection, their contribution involves the provision of innate differentiation and maintenance signals to macrophages, rather than adaptive immune mechanisms.
登录
查看更多内容
影响因子：
5.5
作者：
DELEMARRE, FGA;KORS, N;VANROOIJEN, N
通讯作者：
VANROOIJEN, N
DOI：
10.1073/pnas.0307124101
发表时间：
2004-01-06
影响因子：
11.1
作者：
Kang, YS;Kim, JY;Park, CG
通讯作者：
Park, CG
影响因子：
7.3
作者：
Agyekum, S;Church, A;Cohen, J
通讯作者：
Cohen, J
与病毒感染后持续的抗原相关的长寿命生发中心的诱导。
DOI：
10.1084/jem.183.5.2259
发表时间：
1996-05-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bachmann MF;Odermatt B;Hengartner H;Zinkernagel RM
通讯作者：
Zinkernagel RM
影响因子：
3.7
作者：
Berger, DP;Naniche, D;Oldstone, MBA
通讯作者：
Oldstone, MBA