Spared and impaired sleep-dependent memory consolidation in schizophrenia.
Spared and impaired sleep-dependent memory consolidation in schizophrenia.
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DOI：
10.1016/j.schres.2018.04.019
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发表时间：
2018-09
影响因子：
4.5
通讯作者：
Stickgold R
中科院分区：
文献类型：
--
作者：
Baran B;Correll D;Vuper TC;Morgan A;Durrant SJ;Manoach DS;Stickgold R
精神分裂症的认知缺陷是残疾的最强预测因素，缺乏有效的治疗。这反映了我们对机制的理解有限，因而缺乏治疗目标。在精神分裂症中，受损的睡眠依赖性记忆巩固与睡眠纺锤波活动减少相关，这表明睡眠纺锤波是一种潜在的可治疗机制。在本研究中，我们调查是否睡眠依赖性记忆巩固缺陷精神分裂症是选择性的。精神分裂症患者和健康个体执行三项任务，这些任务已被证明经历睡眠依赖性巩固：单词配对任务（口头陈述性记忆），视觉辨别任务（视觉感知程序记忆）和音调任务（统计学习）。24小时后，在一夜睡眠后进行记忆巩固测试。与对照组相比，精神分裂症患者的词对学习的夜间巩固减少。相比之下，两组显示出类似的显着巩固过夜的视觉感知程序记忆。两组都没有表现出一夜之间的统计学学习巩固。目前的研究结果将精神分裂症患者睡眠依赖性记忆巩固的已知缺陷扩展到言语陈述性记忆，这是一种核心的致残性认知缺陷。相比之下，视觉感知程序记忆则幸免于难。这些发现支持了这样的假设，即精神分裂症患者的睡眠依赖性记忆巩固缺陷是选择性的，可能仅限于依赖于纺锤波的任务。这些发现加强了缺乏睡眠依赖性记忆巩固的重要性，在精神分裂症的认知缺陷，并建议睡眠生理学作为一个潜在的治疗机制。
Cognitive deficits in schizophrenia are the strongest predictor of disability and effective treatment is lacking. This reflects our limited mechanistic understanding and consequent lack of treatment targets. In schizophrenia, impaired sleep-dependent memory consolidation correlates with reduced sleep spindle activity, suggesting sleep spindles as a potentially treatable mechanism. In the present study we investigated whether sleep-dependent memory consolidation deficits in schizophrenia are selective. Schizophrenia patients and healthy individuals performed three tasks that have been shown to undergo sleep-dependent consolidation: the Word Pair Task (verbal declarative memory), the Visual Discrimination Task (visuoperceptual procedural memory), and the Tone Task (statistical learning). Memory consolidation was tested 24h later, after a night of sleep. Compared with controls, schizophrenia patients showed reduced overnight consolidation of word pair learning. In contrast, both groups showed similar significant overnight consolidation of visuoperceptual procedural memory. Neither group showed overnight consolidation of statistical learning. The present findings extend the known deficits in sleep-dependent memory consolidation in schizophrenia to verbal declarative memory, a core, disabling cognitive deficit. In contrast, visuoperceptual procedural memory was spared. These findings support the hypothesis that sleep-dependent memory consolidation deficits in schizophrenia are selective, possibly limited to tasks that rely on spindles. These findings reinforce the importance of deficient sleep-dependent memory consolidation among the cognitive deficits of schizophrenia and suggest sleep physiology as a potentially treatable mechanism.
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影响因子：
56.9
作者：
KARNI, A;TANNE, D;SAGI, D
通讯作者：
SAGI, D
影响因子：
10.6
作者：
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影响因子：
5.3
作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
7.7
作者：
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